Evidence map›Paper›PMID 40112105›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Redox dye-mediated fluorescence energy transfer of carbon nanotube-based nanosensors.

Shoichi Nishitani, Kevin Ao, Amad Jalil, Octavio I Arias-Soto, Ava Moudi, Feiyang Chen, Ankita Biyani, Padma N Muppirala, Markita P Landry

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shoichi NishitaniDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.ORCID 0000-0001-6355-6952
Kevin AoDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Amad JalilDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Octavio I Arias-SotoDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Ava MoudiDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Feiyang ChenDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Ankita BiyaniDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Padma N MuppiralaDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Markita P LandryDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.ORCID 0000-0002-5832-8522

Funding

Alfred P. Sloan Foundation (APSF) N/ABlanche Davis Moore Foundation (Blanche Moore Foundation) N/ABurroughs Wellcome Fund (BWF) N/ACamille and Henry Dreyfus Foundation (Dreyfus Foundation) N/AChan Zuckerberg Initiative (CZI) N/AEvelyn F. McKnight Brain Research Foundation (MBRF) N/ANIH MIRA N/ANIH R03 N/ANSF CAREER N/ANSF CBET N/ANSF CGEM N/APhilomathia Foundation (The Philomathia Foundation) N/A
6 · The paper itself

Abstract

Single-walled carbon nanotubes (SWCNTs) exhibit nonphotobleaching, near-infrared (NIR) fluorescence suitable for bioimaging applications. In particular, SWCNT fluorescence quenching induced by biopolymer dispersants facilitates flexible design of molecular nanosensors, yet challenges remain in analyte selectivity and lack of rational design strategies. A sought-after alternative to haphazard molecular modulation of SWCNT-based fluorescence is to couple the movement of a quencher to the SWCNT surface, enabling fluorescence energy transfer to modulate molecular recognition with high selectivity. This study presents the rational design of SWCNT-based nanosensors with fluorescence energy transfer, leveraging the unique properties of methylene blue (MB) proximity-mediated fluorescence quenching. MB-SWCNT-based nanosensors exhibit 1- stability in redox environments and 2- analyte-specific displacement-driven fluorescence modulation. By designing hybridization-induced displacement of MB-conjugated ssDNA from the SWCNT surface, we calculate that SWCNT fluorescence modulation can occur within a 6.8 nm fluorescence resonance energy transfer distance from the SWCNT surface and develop a robust and versatile platform to synthesize oligonucleotide nanosensors with tunable Δ

Indexed as

Biosensing TechniquesFluorescence Resonance Energy TransferFluorescent DyesNanotubes, CarbonMethylene BlueNanotechnologyOxidation-ReductionFluorescent DyesMethylene BlueNanotubes, Carbonbiosensorenergy transfersingle-walled carbon nanotube

Identifiers

PMID40112105
PMCPMC11962466

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.