Evidence map›Paper›PMID 40112082›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Carotid artery stiffness mechanisms, heart failure events, and atrial fibrillation in MESA: the Multi-Ethnic Study of Atherosclerosis.

Ryan Pewowaruk, Claudia E Korcarz, David A Bluemke, Mohamed H Hamdan, Susan R Heckbert, Joao A C Lima, Yacob Tedla, Adam D Gepner

Abstract readMulticenter Study
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryan PewowarukRyan Pewowaruk Research Consulting, Madison, Wisconsin, United States.
Claudia E KorcarzDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0001-9691-9027
David A BluemkeDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Mohamed H HamdanDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Susan R HeckbertDepartment of Epidemiology, University of Washington School of Public Health, Seattle, Washington, United States.
Joao A C LimaDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States.
Yacob TedlaDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States.
Adam D GepnerDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-5869-2850

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANKOW, JAMES S · 2020 to 2025
$4.4M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00003 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2020 to 2025
$3.8M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00007 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BERTONI, ALAIN GERALD · 2020 to 2025
$3.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00002 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN J · 2020 to 2025
$3.4M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1‐TR‐000040HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1‐TR‐001079HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1‐TR‐001420HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01‐HC‐95159HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01‐HC‐95160HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01‐HC‐95161HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01‐HC‐95162HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01‐HC‐95163HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01‐HC‐95164HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01‐HC‐95165HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01‐HC‐95166HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01‐HC‐95167HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01‐HC‐95168HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01‐HC‐95169NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS T32 HL007936U.S. Environmental Protection Agency (EPA) RD831697U.S. Environmental Protection Agency (EPA) RD‐83830001
6 · The paper itself

Abstract

Arterial stiffness can be separated into two main mechanisms:

Indexed as

AtherosclerosisAtrial FibrillationCarotid ArteriesCarotid Artery DiseasesHeart FailureVascular StiffnessAgedAged, 80 and overFemaleHumansIncidenceMaleMiddle AgedProspective StudiesPulse Wave AnalysisRisk Assessmentarterial stiffnessatrial fibrillationepidemiologyheart failure

Identifiers

PMID40112082
PMCPMC12264796

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.