ArticleInternational urology and nephrology2025
The effects of intragraft CD38+ B cell on chronic active antibody mediated rejection in kidney transplantation.
Article in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aimed to determine the relation between CD38+ B-cell infiltration and outcome of transplant recipients diagnosed with chronic active antibody mediated rejection (caABMR).
methodsA total of 67 patients transplanted from April 2003 and July 2021 with biopsy-proved caABMR were included. The density of CD3+ , CD20+ and CD38+ cells were quantified by immunohistochemical staining and baseline information, estimated glomerular filtration rate (eGFR) and 24 h urine quantitative protein at diagnose were collected. Receiver operating characteristic (ROC) curves were used to calculate the cut-off values in the prediction of graft loss and prognosis factors were further analyzed by Cox proportional-hazards analysis. Kaplan-Meier death-censored graft survivals of subgroups divided by CD38+ B-cell infiltration or urine quantitative protein were compared.
resultsThe median density of CD3+ , CD20+ and CD38+ cells was 278, 167 and 89 (per mm
conclusionA threshold of CD38+ B cell infiltration ≥ 93/mm
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