ArticleMethods in molecular biology (Clifton, N.J.)2025
Development and Validation of Stress Paradigms to Study Astrocytes in Rodent Models of Stress Disorders.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice.Nature communications · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is growing appreciation for astrocytes as essential partners in the central response to stress. Insight from post-mortem human brain tissue has revealed extensive astrocyte remodeling in people who suffered from psychiatric disorders including major depressive disorder. Rodent models of stress disorders align with human data, showing that astrocyte dysfunction directly contributes to cellular and behavioral maladaptation following intense or chronic stress. Despite these links, more research is required to determine astrocyte-specific stress signalling mechanisms and whether these pathways can be targeted in a therapeutic strategy. Here, we detail an early-life stress paradigm that induces lifelong stress susceptibility associated with astrocyte dysfunction. In addition, we provide a detailed guideline to validate a stress model.
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Registered trials
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