Evidence map›Paper›PMID 40111601›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Imaging Techniques for the Analysis of the Blood-Brain Barrier and Gliovascular Unit Dysfunction.

Samantha Golf, Carmen Muñoz-Ballester, Benjamin Heithoff, Kijana George, Stefanie Robel

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samantha GolfDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Carmen Muñoz-BallesterDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Benjamin HeithoffFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VI, USA.
Kijana GeorgeFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VI, USA.
Stefanie RobelDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA. srobel@uab.edu.

Funding

Dynamic temporal regulation of astrocyte coupling to shape neuronal activity during acquired epilepsy developmentR01NS121145 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Stefanie Robel · 2022 to 2026
$1.8M
NINDS NIH HHS R01 NS121145
6 · The paper itself

Abstract

Proper blood-brain barrier (BBB) function is essential to maintain homeostasis, keeping the central nervous system healthy. Disruption of the BBB has been described in nearly all neurological disease and injury contexts. Given the various physical and metabolic roles of the BBB and gliovascular unit (GVU), dysfunction should be assessed across multiple levels to pinpoint the exact nature of the impairment. Here, we describe imaging techniques for evaluating various aspects of BBB and GVU integrity and function, tailored for use in mouse models, and accompanied by protocols for quantitative image analysis. These imaging techniques complement classical dye tracer experiments and reveal underlying molecular causes of BBB dysfunction.

Indexed as

Blood-Brain BarrierNeurogliaAnimalsDisease Models, AnimalMiceAstrocyte endfeetBasement membraneBBBBlood–brain barrierEndothelial cellsImpairmentTight junctions

Identifiers

PMID40111601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.