Evidence map›Paper›PMID 40111502›Full record

ArticleJournal of the American Chemical Society2025

Enantioselective Hydrodifluoroalkylation of Alkenes with Conformationally Tuned Peptidyl Hydrogen Atom Transfer Catalysts.

Marcus Vinicius Pinto Pereira Junior, Eric P Geunes, Huiling Shao, Yiran Zhang, Jinkai Cheng, Samantha V Magpantay, Brandon Q Mercado, James M Mayer, Kendall N Houk, Robert R Knowles and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marcus Vinicius Pinto Pereira JuniorDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Eric P GeunesDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0002-6837-0679
Huiling ShaoDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.ORCID 0000-0001-8007-6408
Yiran ZhangDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Jinkai ChengDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.
Samantha V MagpantayDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Brandon Q MercadoDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
James M MayerDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-3943-5250
Kendall N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.ORCID 0000-0002-8387-5261
Robert R KnowlesDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0003-1044-4900
Scott J MillerDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0001-7817-1318

Funding

Site-Selective Catalysis for Bioactive Scaffold DiversificationR35GM132092 · NIGMS · YALE UNIVERSITY · PI Scott J Miller · 2019 to 2026
$6.3M
New Synthetic Methods Enabled by Excited-State Redox ChemistryR35GM134893 · NIGMS · PRINCETON UNIVERSITY · PI Robert R Knowles · 2020 to 2026
$3.8M
NIGMS NIH HHS R35 GM132092NIGMS NIH HHS R35 GM134893
6 · The paper itself

Abstract

We report the enantioselective hydrodifluoroalkylation of alkenes proceeding via an asymmetric hydrogen atom transfer (HAT) event catalyzed by thiol-containing tetrapeptides. Photocatalytic generation of a difluoroacetyl radical followed by carbon-carbon bond formation results in a prochiral carbon-centered radical that engages with the chiral catalyst. A trialkylamine reductant is proposed to turn over the catalyst in this net-reductive transformation. Notably, incorporating an (

Indexed as

AlkenesHydrogenAlkylationCatalysisDensity Functional TheoryMolecular ConformationStereoisomerismAlkenesHydrogen

Identifiers

PMID40111502
PMCPMC11983094

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.