SynthesisWorld journal of urology2025
Comparison of extended and standard lymph node dissection in radical cystectomy for urothelial bladder cancer: a systematic review and meta-analysis.
Synthesis in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Extended Versus Non-Extended Lymphadenectomy in Radical Cystectomy for Bladder Cancer: A Systematic Review and Meta-Analysis.Journal of surgical oncology · 2026Pooled it
- Robotic Partial Cystectomy and Extended Pelvic Lymph Node Dissection for Node-Positive Urachal Adenocarcinoma in a 34-Year-Old Woman: A Case Report.Current oncology (Toronto, Ont.) · 2026Article
- Advances in the management of localized bladder cancers.Nature reviews. Clinical oncology · 2026Review
- The construction of a predictive model for postoperative bladder paralysis in patients with cervical cancer based on logistic regression and nomogram.Frontiers in oncology · 2026Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLymph node dissection (LND) is an essential part of radical cystectomy (RC) performed with curative intent for invasive urothelial bladder cancer (UBC). This meta-analysis synthesizes evidence from randomized controlled trials (RCTs) comparing outcomes of extended and standard LND during RC.
methodsSystematic searches of PubMed, Scopus, and Web of Science, conducted on November 10, 2024, identified RCTs that compared outcomes of standard (removal of pelvic lymph nodes [LNs]) versus extended LND (removal of pelvic and retroperitoneal LNs) during RC. Intention-to-treat populations were analyzed. Primary outcomes were recurrence-free (RFS) and overall survival (OS).
resultsTwo RCTs involved 993 patients, among whom 490 were randomized to extended and 503 to standard LND. We did not find evidence that RFS (hazard ratio [HR] 1.01, 95% confidence interval [CI] 0.83-1.24) and OS (HR 0.98, 95% CI 0.81-1.19) differed between patients undergoing extended and standard LND. The risk of local recurrence did not differ between extended and standard LND (relative risk [RR] 1.17, 95% CI 0.80-1.72). The risk of major complications (grade > 3) was higher for the extended template (RR 1.22, 95% CI 1.05-1.41), as was the 90-day postoperative mortality (RR 1.93, 95% CI 1.01-3.69). The limited number of studies and sample size constitute major limitations.
conclusionThis meta-analysis demonstrates that extended LND was not associated with improved RFS or OS compared to standard LND, but was linked to increased morbidity. Therefore, pelvic lymphadenectomy up to the common iliac bifurcation should remain the standard of care during RC.
Indexed as
Identifiers
40111501What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.