Evidence map›Paper›PMID 40111498›Full record

ArticleAnnals of hematology2025

Racial disparities in cardiovascular manifestations among patients with sickle cell trait: analysis of national inpatient sample data (2016-2020).

Praneeth Reddy Keesari, Charan Thej Reddy Vegivinti, Medha Rajamanuri, Ahmad Mustafa, Ngowari Pokima, Lauren Haley White, Hasnain Chaudhry, Chamberline E Ozigbu, Khairul A Siddiqi, Suzanne El-Sayegh and 2 more

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Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Praneeth Reddy KeesariDepartment of Internal Medicine, Staten Island University Hospital, Staten Island, NY, USA.
Charan Thej Reddy VegivintiDivision of Hematology Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Medha RajamanuriDepartment of Internal Medicine, Southern Illinois University, Springfield, IL, USA.
Ahmad MustafaDepartment of Cardiovascular Medicine, Staten Island University Hospital, Staten Island, NY, USA.
Ngowari PokimaDepartment of Internal Medicine, Staten Island University Hospital, Staten Island, NY, USA.
Lauren Haley WhiteDepartment of Medicine, Ross University School of Medicine, Two Mile Hill St. Michael, Bridgetown, Barbados.
Hasnain ChaudhryDepartment of Internal Medicine, Staten Island University Hospital, Staten Island, NY, USA.
Chamberline E OzigbuDepartment of Health Services Policy and Management, University of South Carolina, Columbia, SC, USA.
Khairul A SiddiqiCommunity and Behavioral Health, Washington State University Elson S. Floyd College of Medicine, Spokane, WA, USA.
Suzanne El-SayeghDepartment of Internal Medicine, Staten Island University Hospital, Staten Island, NY, USA.
Meekoo DharDepartment of Hematology/Oncology, Staten Island University Hospital, Staten Island, NY, USA.
Ugochi Olivia OguDivision of Hematology, University of Tennessee Health Science Center, Memphis, TN, USA. uogu@uthsc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell trait (SCT) is a condition that affects up to 3 million individuals and 10% of African Americans (AA) in the United States (U.S.). Although often believed to be benign, the true burden of the condition remains understudied. Data is also lacking regarding the racial disparities in SCT and if African American individuals with SCT are at increased cardiovascular risk compared to individuals of other races. Using the National Inpatient Sample (NIS) database, we investigated cardiovascular outcomes in AA individuals with SCT compared to other racial groups. Our study reported statistically significant higher odds of acute heart failure in AA individuals with SCT (Adjusted OR: 1.39 (p < 0.01, 95% CI: 1.13-1.71). Further studies investigating the racial disparities and cardiovascular risk among individuals with SCT are warranted to measure the causal effects.

Indexed as

Cardiovascular DiseasesHealth Status DisparitiesHeart FailureSickle Cell TraitAdolescentAdultAgedBlack or African AmericanDatabases, FactualFemaleHumansInpatientsMaleMiddle AgedUnited StatesYoung AdultAfrican AmericanCardiovascularRacial disparitySickle cell trait

Identifiers

PMID40111498
PMCPMC12031760

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.