Evidence map›Paper›PMID 40111479›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025

Sex-specific associations of vitamin D and bone biomarkers with bone density and physical function during recovery from hip fracture: the Baltimore Hip Studies.

Anne R Cappola, Danielle S Abraham, Jeffrey M Kroopnick, Yi Huang, Marc C Hochberg, Ram R Miller, Michelle Shardell, Gregory E Hicks, Denise Orwig, Jay Magaziner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anne R CappolaDivision of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, 12-136 Smilow Center for Translational Research, 3400 Civic Center Blvd, Philadelphia, PA, 19104-5160, USA. acappola@pennmedicine.upenn.edu.
Danielle S AbrahamDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Jeffrey M KroopnickDivision of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD, USA.
Yi HuangDepartment of Mathematics and Statistics, University of Maryland Baltimore County, Baltimore, MD, USA.
Marc C HochbergDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Ram R MillerNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
Michelle ShardellDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Gregory E HicksDepartment of Physical Therapy, University of Delaware, Newark, DE, USA.
Denise OrwigDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Jay MagazinerDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Sequelae of Hip Fracture in Men: An Epidemiologic StudyR37AG009901 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · 1992 to 2018
$11.3M
RESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000262 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ANN L GRUBER-BALDINI, DENISE L ORWIG · 1998 to 2026
$8.2M
Statistical methods for vitamin D targets for functional outcomes in older adultsR01AG048069 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2015 to 2025
$4.3M
The Epidemiology of Bone Strength and Muscle Composition After Hip Fracture in MeR01AG029315 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · 2007 to 2011
$4.1M
Midcareer Investigator Award in Patient-Oriented Research in AgingK24AG042765 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CAPPOLA, ANNE R · 2013 to 2024
$1.7M
NCATS NIH HHS ULTR003098NIA NIH HHS K24 AG042765NIA NIH HHS K24AG042765NIA NIH HHS P30 AG028747NIA NIH HHS P30AG028747NIA NIH HHS R01 AG029315NIA NIH HHS R01AG029315NIA NIH HHS R01 AG048069NIA NIH HHS R01AG048069NIA NIH HHS R37 AG009901NIA NIH HHS R37AG009901NIA NIH HHS T32 AG000262NIA NIH HHS T32AG00262
6 · The paper itself

Abstract

Less is known about recovery from hip fracture in men. We found differences in 25-hydroxyvitamin D and bone biomarkers between men and women during the year after hip fracture, underscoring the importance of vitamin D assessment in older men and pharmaceutical treatment to reduce bone resorption after hip fracture. PURPOSE: Less is known about recovery from hip fracture in men compared to women. We examined differences between men and women in 25-hydroxyvitamin D (25OHD) and bone turnover markers, and associations with bone mineral density (BMD) and physical function, during the year after a hip fracture.

methodsCommunity-dwelling, ambulatory adults aged 65 years and over (157 men and 154 women) enrolled in the Baltimore Hip Studies 7th cohort were included. We analyzed 25OHD, C-terminal telopeptide (β-CTX-I), procollagen type I N-terminal propeptide (PINP), PTH, and femoral neck BMD at baseline, 2, 6, and 12 months after hip fracture, and short physical performance battery (SPPB) at 2, 6, and 12 months.

resultsDuring admission for hip fracture, median 25OHD levels were 15.2 ng/mL (IQR 10.0) in men compared with 23.9 ng/mL (IQR 13.4) in women and remained lower in men at 2, 6, and 12 months (all p < 0.001). β-CTX-I was higher in men on admission, and at 2 and 6 months (all p < 0.05), and PINP was higher in men at 6 months (p = 0.04), with no significant differences between men and women in PTH. Higher 25OHD and PINP concentrations in women only and lower β-CTX-I and PTH concentrations in both sexes were associated with greater BMD. Higher 25OHD concentrations were associated with higher SPPB scores in both sexes.

conclusionsThese findings underscore the importance of vitamin D assessment in older men and missed opportunities in both sexes for vitamin D supplementation and pharmaceutical treatment to reduce bone resorption after hip fracture.

Indexed as

Bone DensityHip FracturesOsteoporotic FracturesVitamin DAgedAged, 80 and overBiomarkersBone RemodelingCollagen Type IFemaleFemur NeckHumansMalePeptidesPhysical Functional PerformanceRecovery of Function25-hydroxyvitamin DBiomarkersCollagen Type Icollagen type I trimeric cross-linked peptidePeptidesVitamin D25-Hydroxyvitamin DC-TelopeptideDXAProcollagen type 1 amino-terminal propeptideShort physical performance battery

Identifiers

PMID40111479
PMCPMC12089210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.