Evidence map›Paper›PMID 40111391›Full record

ArticleeLife2025

Novel mechanism for tubular injury in nephropathic cystinosis.

Swastika Sur, Maggie Kerwin, Silvia Pineda, Poonam Sansanwal, Tara K Sigdel, Marina Sirota, Minnie M Sarwal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Cystinosis and Cellular Energy Failure: Mitochondria at the Crossroads.International journal of molecular sciences · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Swastika SurDivision of Multi-Organ Transplantation, Department of Surgery, University of California, San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0001-9536-981X
Maggie KerwinDivision of Multi-Organ Transplantation, Department of Surgery, University of California, San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0002-6792-342X
Silvia PinedaDivision of Multi-Organ Transplantation, Department of Surgery, University of California, San Francisco, San Francisco, United States.
Poonam SansanwalDivision of Multi-Organ Transplantation, Department of Surgery, University of California, San Francisco, San Francisco, United States.
Tara K SigdelDivision of Multi-Organ Transplantation, Department of Surgery, University of California, San Francisco, San Francisco, United States.
Marina SirotaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, United States.
Minnie M SarwalDivision of Multi-Organ Transplantation, Department of Surgery, University of California, San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0003-1212-3959

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the unique susceptibility of the human kidney to pH dysfunction and injury in cystinosis is paramount to developing new therapies to preserve renal function. Renal proximal tubular epithelial cells (RPTECs) and fibroblasts isolated from patients with cystinosis were transcriptionally profiled. Lysosomal fractionation, immunoblotting, confocal microscopy, intracellular pH, TEM, and mitochondrial stress test were performed for validation. CRISPR,

Indexed as

CystinosisKidney Tubules, ProximalAmino Acid Transport Systems, NeutralAutophagyCells, CulturedEpithelial CellsFibroblastsHumansHydrogen-Ion ConcentrationLysosomesMitochondriaVacuolar Proton-Translocating ATPasesAmino Acid Transport Systems, NeutralCTNS protein, humanVacuolar Proton-Translocating ATPasesautophagycell biologyCKDCystinosisgenetic renalhumankidney diseaselysosomal storage disorder

Identifiers

PMID40111391
PMCPMC11925453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.