Evidence map›Paper›PMID 40111255›Full record

ArticleMicrobial genomics2025

Plasmid conjugation drives within-patient plasmid diversity.

Fan Grayson, Leo Loman, Toby Nonnenmacher, Diane Pople, Jack Pollard, Bharat Patel, David Williams, Luke Hounsome, Katie L Hopkins, Julie V Robotham and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The extended mobility of plasmids.Nucleic acids research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fan GraysonAdvanced Analytics, Analysis & Intelligence Assessment, Chief Data Officer Group, UK Health Security Agency, London, UK.
Leo LomanAdvanced Analytics, Analysis & Intelligence Assessment, Chief Data Officer Group, UK Health Security Agency, London, UK.
Toby NonnenmacherChief Data Officer Group Private Office, Chief Data Officer Group, UK Health Security Agency, London, UK.
Diane PopleHCAI & AMR Modelling and Evaluation, AMR & HCAI Division, UK Health Security Agency, London, UK.
Jack PollardHCAI & AMR Modelling and Evaluation, AMR & HCAI Division, UK Health Security Agency, London, UK.
Bharat PatelPublic Health Microbiology Division, Science Group, UK Health Security Agency, London, UK.
David WilliamsHCAI & AMR Modelling and Evaluation, AMR & HCAI Division, UK Health Security Agency, London, UK.
Luke HounsomeAdvanced Analytics, Analysis & Intelligence Assessment, Chief Data Officer Group, UK Health Security Agency, London, UK.
Katie L HopkinsAntimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, Public Health Microbiology Division, UK Health Security Agency, London, UK.
Julie V RobothamHCAI & AMR Modelling and Evaluation, AMR & HCAI Division, UK Health Security Agency, London, UK.
Alice LeddaHCAI & AMR Modelling and Evaluation, AMR & HCAI Division, UK Health Security Agency, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmids are well-known vehicles of antimicrobial resistance (AMR) gene dissemination. Through conjugation, plasmid-encoded AMR genes are spread among neighbouring bacteria, irrespective of their strain or even their species. This process is very concerning from a public health perspective, as plasmid-borne AMR gene outbreaks are often not confined to single species or strains and are therefore more difficult to fully uncover. At the moment, the impact of plasmid conjugation on within-patient plasmid diversity is not well understood. In this work, we will tackle the role of conjugation on within-patient plasmid diversity using a dataset of carbapenemase-producing

Indexed as

Conjugation, GeneticEnterobacteriaceaePlasmidsBacterial Proteinsbeta-LactamasesDrug Resistance, BacterialGenetic VariationHumansBacterial Proteinsbeta-Lactamasescarbapenemaseantimicrobial resistance (AMR)carbapenem resistancegenomic epidemiologyplasmidspublic health

Identifiers

PMID40111255
PMCPMC11925198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.