Evidence map›Paper›PMID 40111153›Full record

ArticleHuman gene therapy2025

Overexpression of ABCA1 in Carotid Endothelium of Hyperlipidemic Rabbits Modulates Vascular Inflammation.

Bradley K Wacker, Lianxiang Bi, Goren Saenz-Pipaon, Nicole Sanford, Abigail Z Regan, Natalie S Lim, Li Liu, Francis Kim, David A Dichek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human gene therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bradley K WackerDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-1906-0316
Lianxiang BiDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Goren Saenz-PipaonDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Nicole SanfordDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Abigail Z ReganDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Natalie S LimDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Li LiuDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Francis KimDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.
David A DichekDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.

Funding

Atheroprotective Gene TherapyR01HL114541 · NHLBI · UNIVERSITY OF WASHINGTON · PI DICHEK, DAVID A · 2013 to 2022
$4.9M
NHLBI NIH HHS R01 HL114541
6 · The paper itself

Abstract

Endothelial activation and dysfunction are key early steps in atherogenesis. Vascular gene therapy targeting endothelial inflammation and cholesterol accumulation could decrease atherosclerosis progression. ATP-binding cassette subfamily A member 1 (ABCA1) exhibits anti-inflammatory properties and promotes cholesterol efflux. A mouse model showed that systemic endothelial overexpression of ABCA1 decreased diet-induced atherosclerosis. To test if local ABCA1 endothelial overexpression protects against atherosclerosis, we used helper-dependent adenoviral vectors (HDAd) to express ABCA1 or a "Null" control in the carotid endothelium of hyperlipidemic rabbits. Both

Indexed as

AtherosclerosisATP Binding Cassette Transporter 1Carotid ArteriesEndothelium, VascularHyperlipidemiasInflammationAdenoviridaeAnimalsDiet, High-FatDisease Models, AnimalGenetic TherapyGenetic VectorsHumansMacrophagesMaleRabbitsATP Binding Cassette Transporter 1adenovirusatherosclerosiscarotid arteryendotheliumgene therapyrabbit

Identifiers

PMID40111153
PMCPMC12042661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.