ArticleAddiction biology2025
White Matter Differences in Early-Stage Alcohol Use Disorder: Diffusion Tensor and Neurite Orientation Dispersion and Density Measures of Structural Integrity.
Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
backgroundAlcohol use disorder (AUD) is prevalent during young adulthood, and this risk may be linked to aberrations in neurodevelopmental processes. Prior studies examining white matter (WM) integrity in young adult individuals with AUD have shown considerable variability. This is due in part because traditional tensor related metrics such as fractional anisotropy are subject to limitations in estimation precision at sites of crossing or curving fibres. In response, to better understand differences in WM integrity of young adults with AUD, this study sought to uniquely employ two WM integrity measurement domains.
methodsTwenty-five participants (n = 14 female) diagnosed with AUD and 33 social drinkers (n = 19 female) underwent structural and diffusion-weighted imaging. Diffusion-weighted images were processed to extract diffusion tensor (DTI) and neurite orientation dispersion and density (NODDI) metrics in major WM tracts for comparison between the two groups.
resultsWe identified decreased axial diffusivity in portions of frontolimbic and corticostriatal WM tracts, and increased orientation dispersion at overlapping tracts in participants with AUD relative to social drinkers.
conclusionsThese results may represent early-stage neural immune system activation and axonal reorganization targeting frontolimbic and corticostriatal WM tracts, therein associated with behaviours linked to AUD. This is the first study combining DTI and NODDI metrics to identify early-stage indicators of alcohol-related neurobiological pathology in young adults with AUD compared to social drinkers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.