Evidence map›Paper›PMID 40110949›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Rapid Stereochemical Analysis of Glycosylations in Flow by Ion Mobility Spectrometry.

Jakob B Wolf, Martin Zühlke, Dominik Weh, Marlene C S Dal Colle, Christian Thoben, Toralf Beitz, Klaus Bienert, Dario Cambié, Eric T Sletten, Martina Delbianco and 2 more

Abstract read
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In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jakob B WolfMax Planck Institute of Colloids and Interfaces, Potsdam Science Park, Am Mühlenberg 1, Potsdam, 14476, Germany.ORCID https://orcid.org/0000-0003-0201-2745
Martin ZühlkePhysical Chemistry, Universität Potsdam, Karl-Liebknecht-Straße 24-25, Potsdam, 14476, Germany.ORCID https://orcid.org/0000-0002-6599-4777
Dominik WehMax Planck Institute of Colloids and Interfaces, Potsdam Science Park, Am Mühlenberg 1, Potsdam, 14476, Germany.
Marlene C S Dal ColleMax Planck Institute of Colloids and Interfaces, Potsdam Science Park, Am Mühlenberg 1, Potsdam, 14476, Germany.ORCID https://orcid.org/0009-0006-1062-0395
Christian ThobenDepartment of Sensors and Measurement Technology, Institute of Electrical Engineering and Measurement Technology, Leibniz University Hannover, Hannover, 30167, Germany.ORCID https://orcid.org/0000-0002-5415-2320
Toralf BeitzPhysical Chemistry, Universität Potsdam, Karl-Liebknecht-Straße 24-25, Potsdam, 14476, Germany.ORCID https://orcid.org/0000-0002-5537-913X
Klaus BienertMax Planck Institute of Colloids and Interfaces, Potsdam Science Park, Am Mühlenberg 1, Potsdam, 14476, Germany.
Dario CambiéMax Planck Institute of Colloids and Interfaces, Potsdam Science Park, Am Mühlenberg 1, Potsdam, 14476, Germany.ORCID https://orcid.org/0000-0003-2722-5106
Eric T SlettenMax Planck Institute of Colloids and Interfaces, Potsdam Science Park, Am Mühlenberg 1, Potsdam, 14476, Germany.ORCID https://orcid.org/0000-0003-2177-2969
Martina DelbiancoMax Planck Institute of Colloids and Interfaces, Potsdam Science Park, Am Mühlenberg 1, Potsdam, 14476, Germany.ORCID https://orcid.org/0000-0002-4580-9597
Stefan ZimmermannDepartment of Sensors and Measurement Technology, Institute of Electrical Engineering and Measurement Technology, Leibniz University Hannover, Hannover, 30167, Germany.ORCID https://orcid.org/0000-0002-1725-6657
Peter H SeebergerMax Planck Institute of Colloids and Interfaces, Potsdam Science Park, Am Mühlenberg 1, Potsdam, 14476, Germany.ORCID https://orcid.org/0000-0003-3394-8466

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycans are biologically important molecules that are difficult to synthesize and analyze due to their structural diversity and conformational flexibility. Stereoselective glycosylation reactions are key to achieving high-yielding glycan syntheses. The stereochemical outcome of glycosylations is significantly influenced by factors such as the choice of activator and leaving group systems, solvent type, temperature, concentration, and stoichiometry. We introduce a flow chemistry approach to efficiently screen glycosylation conditions, using minimal material and time to enable a rapid design-make-test-analyze cycle with precise parameter control for reaction optimization. Ion mobility spectrometry provides rapid separation and analysis of crude glycosylation reaction mixtures that requires less method development than liquid chromatography thus making it a valuable tool for optimizing glycosylation reactions.

Indexed as

chemical glycosylationflow chemistryion mobility spectrometryreaction screeningstereoselectivity

Identifiers

PMID40110949
PMCPMC12057612

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.