Evidence map›Paper›PMID 40110909›Full record

Trial reportPhysiological reports2025

Cold pressor-induced sympathetic activation blunts the femoral but not carotid artery vascular responsiveness.

Guilherme F Speretta, Gaia Giuriato, Gianluigi Dorelli, Chiara Barbi, Anna Pedrinolla, Massimo Venturelli

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guilherme F SperettaDepartment of Physiological Sciences, Biological Sciences Center, Federal University of Santa Catarina, Florianopólis, Brazil.ORCID https://orcid.org/0000-0003-3474-1264
Gaia GiuriatoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-8149-9450
Gianluigi DorelliDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-9004-7587
Chiara BarbiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-0043-1148
Anna PedrinollaDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0001-8888-619X
Massimo VenturelliDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-2469-8787

Funding

International Visiting Professor Grant of the University of Verona 1643
6 · The paper itself

Abstract

Vascular responsiveness due to passive leg movement (PLM) on the brain remains unknown. This study aimed to evaluate the effects of cold-induced sympathetic activation (CPT) on femoral and ipsilateral and contralateral carotid arteries' vascular responsiveness evoked by PLM. Thirteen participants (seven males and six females; age: 27.0 ± 2.3 years) undertook a randomized session in which PLM was performed on the right leg at rest and during CPT. Right femoral (fBF) and right (ipsilateral) and left (contralateral) carotid (cBF) blood flows were measured by ultrasounds, and heart hemodynamics were assessed via photoplethysmography and impedance cardiograph. Systolic arterial pressure (SAP) time series were used to infer sympathetic modulation to the vessels. Femoral (fVC) and carotid (cVC) vascular conductance (BF/MAP) were calculated. CPT evoked changes in PLM on cBF, fBF, and fVC (interaction and time effect). cBF peak and cBF and cVC area under the curve were higher in the contralateral carotid in the two interventions. Low-frequency power of SAP was higher in PLM-CPT than in PLM; all p < 0.05. These results suggest that the CPT-induced increases in sympathetic modulation attenuate the vascular responsiveness in the femoral, but not the carotid, arteries. Also, the contralateral carotid increased blood flow during PLM, regardless of the CPT.

Indexed as

Carotid ArteriesCold TemperatureFemoral ArterySympathetic Nervous SystemAdultBlood PressureCross-Over StudiesFemaleHemodynamicsHumansLegMaleMovementRegional Blood FlowYoung Adultblood flowblood pressure variabilitycold pressor testhemodynamicsvascular conductance

Identifiers

PMID40110909
PMCPMC11923985

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.