ArticlePhysiological reports2025
The effects of volitional hyperpnea on biomarkers of respiratory muscle damage in healthy young men.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Responses to Voluntary Isocapnic Hyperpnea in Normoxia and Hypoxia: Insights from Blood Gas Analysis.Biology · 2025Article
- The effects of volitional hyperpnea on biomarkers of respiratory muscle damage in healthy young men.Physiological reports · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-intensity exercise hyperpnea places substantial demands upon the respiratory muscles, but whether this causes respiratory muscle damage is unknown. We investigated respiratory muscle damage following volitional hyperpnea (equivalent to 85% of participants maximum minute ventilation produced during a maximal incremental cycling test) using a skeletal muscle damage biomarker panel. Eight healthy men (33 + 2 years) underwent 10-min trials of volitional hyperpnea and rest (control) two weeks apart. Serum was collected before and at 1, 24, and 48 h after both volitional hyperpnea and control trials. Creatine kinase muscle-type (CKM), fast skeletal troponin I (sTnI) and slow sTnI were measured using enzyme-linked immunosorbent assay. Two-way analysis of variance revealed time × trial interaction effects for slow sTnI (p = 0.018), but not for CKM (p = 0.072) and fast sTnI (p = 0.140). Slow sTnI was significantly higher at +24 h post volitional hyperpnea (p < 0.001) as compared to the same time point of the control trial. These results indicate that high-intensity exercise hyperpnea may induce a small amount of respiratory muscle damage as evidenced by the increases in slow sTnI. Future studies including more time points, different respiratory muscle exercise protocols, and examining the differences between sexes could provide additional insights into the utility of blood biomarkers for identifying respiratory muscle damage.
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