Evidence map›Paper›PMID 40110699›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort: An exploratory study.

Apoorva Safai, William R Buckingham, Erin M Jonaitis, Rebecca E Langhough, Sterling C Johnson, W Ryan Powell, Amy J Kind, Barbara B Bendlin, Pallavi Tiwari

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Multimorbidity, Polypharmacy, and Neighborhood Disadvantage as Determinants of Cognitive Performance in the ARCHES Cohort.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Apoorva SafaiDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
William R BuckinghamCenter for Health Disparities Research, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Erin M JonaitisDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Rebecca E LanghoughDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sterling C JohnsonDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
W Ryan PowellCenter for Health Disparities Research, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Amy J KindCenter for Health Disparities Research, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Barbara B BendlinCenter for Health Disparities Research, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Pallavi TiwariDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Funding

The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)R01AG070883 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2021 to 2026
$42.1M
Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
Neighborhood Socioeconomic Contextual Disadvantage and Alzheimer's DiseaseRF1AG057784 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA, KIND, AMY J. · 2017 to 2017
$3.8M
Neighborhood Socioeconomic Disadvantage and Medicare's 30-Day Rehospitalization Policy: Eliminating Rehospitalization Disparities by Informing Policy Design and ImplementationR01MD010243 · NIMHD · UNIVERSITY OF WISCONSIN-MADISON · PI KIND, AMY J. · 2015 to 2019
$2.8M
NIA NIH HHS R01 AG027161NIA NIH HHS R01AG027161NIA NIH HHS R01 AG070883NIA NIH HHS R01AG070883NIA NIH HHS RF1 AG057784NIA NIH HHS RF1AG057784NIMHD NIH HHS R01 MD010243UW-Madison Radiology start up fund
6 · The paper itself

Abstract

introductionNeighborhood disadvantage has been shown to impact health and cognitive outcomes, while morphological similarity network (MSN) can elucidate structural morphological patterns underlying cognitive functions. We hypothesized MSNs could provide cortical patterns linked with neighborhood disadvantage and cognitive function, explaining the potential risk of cognitive impairment in disadvantaged neighborhoods.

methodsFor cognitively unimpaired participants from the Wisconsin Alzheimer's Disease Research Center or Wisconsin Registry for Alzheimer's Prevention (n = 524), and the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (n = 100), neighborhood disadvantage was obtained using Area Deprivation Index (ADI) and its association with cognitive performance and MSN features was analyzed using linear regression and mediation analysis.

resultsNeighborhood disadvantage was associated with worse cognitive performance on memory, executive function, processing speed, and preclinical Alzheimer's tests on both datasets. Local morphological organization of predominantly the frontal and temporal regions showed association trends with ADI. DISCUSSION: Morphological patterns associated with ADI, in-part, may explain the risk for poor cognitive functioning in a neighborhood disadvantaged population. HIGHLIGHTS: Social determinants of health such as neighborhood context can be studied using ADI. High neighborhood disadvantage was related to worse performance on category fluency, implicit learning speed, story recall memory and pre-clinical Alzheimer's cognitive composite. In this exploratory study, using morphological brain networks that indicate similarity in distribution of cortical thickness between regions, we observed that centrality of predominantly frontal and temporal regions was marginally linked with neighborhood disadvantage status and also partially mediated its association with preclinical Alzheimer's composite test. There is a potential role for considering neighborhood status in early screening of cognitive impairment and dementia.

Indexed as

Cerebral CortexCognitionCognitive DysfunctionNeighborhood CharacteristicsResidence CharacteristicsAgedAged, 80 and overAlzheimer DiseaseCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleNeuropsychological TestsWisconsinAlzheimer's diseasearea deprivation indexcognitive functionmorphological similarity networksneighborhood disadvantagesocial determinant of health

Identifiers

PMID40110699
PMCPMC11923708

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.