ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Social determinants of health and risk of dementia among older men and women: A 12-year cohort study in Australia.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Considerations in Alzheimer's Disease in Women.Current neurology and neuroscience reports · 2026Review
- Social determinants of health, behavioral factors, and incident dementia: a prospective cohort study.Alzheimer's research & therapy · 2026Article
- Relationship between subjective well-being and cognitive performance in older adults.Dementia & neuropsychologia · 2026Article
- Cognitive trajectories of older adults before and after the COVID-19 pandemic: socioeconomic and psychological disparities in the Lc65+ cohort.Innovation in aging · 2026Article
- Dilemmas of early dementia screening among community-dwelling older adults: a qualitative study from the perspective of social determinants of health.Frontiers in public health · 2026Article
- The dual impact of social prescribing: targeting social determinants to enhance quality of life in chronic conditions.BMC primary care · 2025Article
- Gender-Specific Population Attributable Fractions for Cardiovascular Disease and All-Cause Mortality Associated with Living Arrangement in Community-Dwelling Older People.Journal of general internal medicine · 2025Article
- Public Health Campaign to Prevent Dementia: An Unmet and Critical Need.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2025Article
- Social determinants of health and risk of dementia among older men and women: A 12-year cohort study in Australia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Childcare engagement among older adults in Australia and subsequent physical, psychosocial, and behavioral health outcomes.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Social determinants of health, genetic biomarkers, and cognitive function in Chinese older adults with subjective cognitive decline and mild cognitive impairment: A cross-sectional analysis.Journal of Alzheimer's disease reportsArticle
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Authors and funding
10 authors.
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Abstract
introductionSocial determinants of health (SDH) are recognized as contributing factors to cognitive disorders, but their collective influence on dementia risk remains unclear.
methodsA gender-disaggregated analysis was conducted on 12,896 community-dwelling older Australians (mean ± SD age: 75.2 ± 4.3 years; 54% women) without major cognitive impairment upon enrollment. Latent class analysis identified clusters from 72 SDH (70 individual-level and 2 neighborhood-level), while Cox proportional hazards regression estimated dementia risk over 12 years (median: 8.4) follow-up.
resultsFour clusters were identified: least disadvantaged (Class 1: 31.5% men; 30.6% women), most disadvantaged (Class 2: 20.2% men; 19.4% women), high social support with Class 1 features (Class 3: 22.2% men; 24.1% women), and high social support with Class 2 features (Class 4: 26.1% men; 25.7% women). Compared to Class 1, men (HR: 1.49, 95% CI: 1.12-1.98) and women (HR: 1.56, 95% CI: 1.17-2.07) in Class 2, and women in Class 4 (HR: 1.66, 95% CI: 1.28-2.16) had a higher dementia risk. DISCUSSION: Socioeconomic disadvantage was associated with incident dementia. Despite stronger social support, women's cognitive capacity appeared to be disproportionately impacted by adverse SDH. HIGHLIGHTS: Four distinct multidimensional clusters were identified from a wide range of 72 social determinants of health. These clusters were associated with dementia risk differently in men and women. In both men and women, the most socioeconomically disadvantaged group had a higher risk of dementia. Despite stronger interpersonal social support, women had a greater risk of dementia. The addition of known dementia risk factors in cluster analysis did not change the findings, suggesting that social determinants of health independently predict dementia risk.
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