ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Association between healthy lifestyle and cognitive decline, all-cause mortality, and mortality from cardiovascular and cerebrovascular diseases: a 10-year population-based prospective cohort study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Association between Cognitive Function and Postoperative Stroke Following Off-Pump Coronary Artery Bypass Grafting.Journal of cardiovascular translational research · 2026Article
- Circadian syndrome (CircS) and cognitive trajectory deterioration in middle-aged and older adults: A national cohort study with causal forest analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The association between depression, anxiety, sleep disturbances and dementia: a prospective cohort study of 350,186 adults.BMC neurology · 2026Article
- Geriatric syndromes and intrinsic capacity in older adults with coronary heart disease: a cross-sectional study in China.Frontiers in public health · 2026Article
- Relative contributions of lifestyle factors to stage-specific progression and mortality in cardiovascular-kidney-metabolic syndrome: a prospective cohort study with multi-state models.Frontiers in public health · 2026Article
- Association between healthy lifestyle and cognitive decline, all-cause mortality, and mortality from cardiovascular and cerebrovascular diseases: a 10-year population-based prospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors.
Funding
Abstract
introductionThe association between cognitive function, healthy lifestyle, and mortality remains understudied in large Chinese cohorts.
methodsIn this nationwide 10-year prospective study of 24,657 older adults, we assessed Mini-Mental State Examination (MMSE) categories (<18, 18 to 23, 24 to 27, 28 to 30) and a seven-component lifestyle score (0 to 7) for their relationships with all-cause, cardiovascular, and cerebrovascular mortality.
resultsCompared with individuals scoring 28 to 30 on the MMSE, lower scores were linked to elevated all-cause and cerebrovascular mortality but not cardiovascular mortality. Participants with lifestyle scores of 4 or 5 had a higher risk of all-cause mortality. Even optimal lifestyle practices did not fully mitigate the heightened mortality risk associated with declining cognitive performance. DISCUSSION: A healthy lifestyle is beneficial but cannot fully offset the impact of cognitive impairment. Therefore, integrating routine cognitive assessments and targeted interventions with healthy lifestyle practices is crucial for effectively reducing mortality risk. HIGHLIGHTS: A nationally representative, 10-year prospective cohort in China was employed to investigate the combined effects of lifestyle behaviors and cognitive function on all-cause, cardiovascular, and cerebrovascular mortality. Both healthy lifestyle and better cognitive function were associated with a reduced risk of all-cause mortality. Even among individuals practicing optimal lifestyle behaviors, cognitive impairment significantly elevated the risk of all-cause and cerebrovascular mortality. These findings underscore the necessity of incorporating routine cognitive assessments and targeted interventions with healthy lifestyle practices aimed at reducing mortality risk in aging populations.
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