ArticleJournal of veterinary internal medicine
Effects of Paricalcitol on Renal Secondary Hyperparathyroidism and Proteinuria in Dogs With Chronic Kidney Disease.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Serum vitamin D metabolites do not differ between cats with chronic kidney disease and healthy cats.Journal of feline medicine and surgery · 2026Article
- Effect of dietary Ca:P ratio on ionized calcium and calcium homeostasis in cats with early-stage chronic kidney disease.PloS one · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundRenal secondary hyperparathyroidism (RHPT) is an inevitable consequence of chronic kidney disease (CKD). Paricalcitol might safely attenuate RHPT and proteinuria. HYPOTHESIS/
objectiveParicalcitol decreases parathyroid hormone (PTH) and proteinuria in dogs with CKD. ANIMALS: Thirteen dogs with naturally acquired CKD.
methodsPlacebo-controlled clinical trial. Dogs were randomly allocated to receive a placebo or paricalcitol (14 ng/kg/day) in a crossover design of 2, 12-week arms. Dogs were evaluated every 3 weeks. Associations between treatment, visit, and the outcome variables were assessed using generalized estimating equations.
resultsPTH decreased by 22% (95% CI, 7%-35%, p = 0.006) in the paricalcitol-treated dogs and increased by 18% (95% CI, 2%-37%, p = 0.022) in the placebo-treated dogs with each visit. FGF-23 at 12 weeks increased compared with baseline in the paricalcitol-treated (mean 6941 pg/mL, 95% CI, 1781-20 057 vs. 489 pg/mL, 95% CI, 188-1272, p < 0.001, respectively), but not in the placebo-treated dogs (696 pg/mL, 95% CI, 316-1531 vs. 955 pg/mL, 95% CI, 308-2963, p = 0.529). Urine protein-to-creatinine ratio at 12 weeks increased compared with baseline in the placebo-treated (0.8, 95% CI, 0.3-1.3 vs. 0.5, 95% CI, 0.2-0.9, p = 0.04, respectively), but not in the paricalcitol-treated dogs (0.6, 95% CI, 0.3-0.9 vs. 1.0, 95% CI, 0.1-1.8, p = 0.35). Ionized calcium was unchanged between baseline and 12 weeks in the paricalcitol- and placebo-treated groups (1.3 mmol/L, 95% CI, 1.29-1.35 and 1.34, 95% CI, 1.27-1.40 vs. 1.30, 95% CI, 1.25-1.35, p = 0.12 and 1.28, 95% CI, 1.24-1.32, p = 0.034, respectively). However, 7/13 dogs developed mild hypercalcemia. Adverse effects were not reported by the owners. CONCLUSION AND CLINICAL IMPORTANCE: Paricalcitol attenuated RHPT and stabilized renal proteinuria in dogs with CKD.
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