ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of Alzheimer's disease-vulnerable regions.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Association of sleep duration with Alzheimer's disease and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Within- and between-person associations of sleep characteristics with daily cognitive performance in a community-based sample of older adults.Sleep health · 2026Article
- The use of electroencephalography in neurodegenerative disease and its utility in dementia.NPJ dementia · 2026Review
- Sleep Abnormalities and Risk of Alzheimer's Disease.Current neurology and neuroscience reports · 2025Review
- Sleep Disorders in Neurodegenerative Diseases with Dementia: A Comprehensive Review.Journal of clinical medicine · 2025Review
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Abstract
STUDY
objectivesSleep deficiency is associated with Alzheimer's disease (AD) pathogenesis. We examined the association of sleep architecture with anatomical features observed in AD: (1) atrophy of hippocampus, entorhinal, inferior parietal, parahippocampal, precuneus, and cuneus regions ("AD-vulnerable regions") and (2) cerebral microbleeds (CMBs).
methodsIn 270 participants of the Atherosclerosis Risk in the Communities Study, we examined the association of baseline sleep architecture with anatomical features identified on brain magnetic resonance imaging 13-17 years later. Sleep architecture was quantified as the proportion of slow wave sleep (SWS), proportion of rapid eye movement (REM) sleep, and arousals index using polysomnography. Outcomes included (1) volumetric measurements of each AD-vulnerable region and (2) the presence of any CMBs and that of lobar CMBs, which are more specifically associated with AD. We analyzed the association of each sleep predictor with each magnetic resonance imaging outcome, adjusting for covariates.
resultsMedian age was 61, 53% were female, 100% were White, and 47% had 16+ years of education. Median times in SWS and REM were 17.4% and 21.5%, respectively. Having less SWS was associated with smaller volumes of the inferior parietal region (β = -44.18 mm
conclusionsSleep deficiency is associated with the atrophy of the inferior parietal region, which is observed in early AD. Sleep architecture may be a modifiable risk factor for AD. CITATION: Cho G, Mecca AP, Buxton OM, Liu X, Miner B. Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of Alzheimer's disease-vulnerable regions.
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