Evidence map›Paper›PMID 40110562›Full record

ArticleBioinformatics advances2025

LipidSigR: a R-based solution for integrated lipidomics data analysis and visualization.

Chia-Hsin Liu, Pei-Chun Shen, Meng-Hsin Tsai, Hsiu-Cheng Liu, Wen-Jen Lin, Yo-Liang Lai, Yu-De Wang, Mien-Chie Hung, Wei-Chung Cheng

Abstract read
In one paragraph

Article in Bioinformatics advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chia-Hsin LiuCancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.
Pei-Chun ShenCancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.
Meng-Hsin TsaiCancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.
Hsiu-Cheng LiuCancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.
Wen-Jen LinSchool of Medicine, China Medical University, Taichung 404328, Taiwan.
Yo-Liang LaiDepartment of Radiation Oncology, China Medical University, Taichung 404328, Taiwan.
Yu-De WangGraduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan.
Mien-Chie HungCancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.
Wei-Chung ChengCancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.ORCID https://orcid.org/0000-0002-1229-4857

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motivation: Lipidomics is a rapidly expanding field focused on studying lipid species and classes within biological systems. As the field evolves, there is an increasing demand for user-friendly, open-source software tools capable of handling large and complex datasets while keeping pace with technological advancements. LipidSig, a widely used web-based platform, has been instrumental in data analysis and visualization of lipidomics. However, its limitations become evident when users want to build customized workflows. To address the limitation, we developed a companion R package, LipidSigR, based on the R code of the LipidSig web platform. Results: LipidSigR offers greater flexibility, allowing researchers with basic R programming skills to modify and adapt workflows according to their needs. It has been rigorously tested following CRAN guidelines to ensure compatibility and reproducibility. In demonstrating its functionality, we analyze the case with commonly used experimental design, case versus control, in lipidomics studies. Researchers can follow the use case to explore the key capabilities and build customized lipidomics data analysis workflows using LipidSigR. Availability and implementation: LipidSigR is freely available from https://lipidsig.bioinfomics.org/lipidsigr/index.html and https://github.com/BioinfOMICS/LipidSigR.

Identifiers

PMID40110562
PMCPMC11919814

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.