Evidence map›Paper›PMID 40110515›Full record

ArticleClinical psychological science : a journal of the Association for Psychological Science2025

Do polygenic indices capture "direct" effects on child externalizing behavior problems? Within-family analyses in two longitudinal birth cohorts.

Peter T Tanksley, Sarah J Brislin, Jasmin Wertz, Ronald de Vlaming, Natasia S Courchesne-Krak, Travis T Mallard, Laurel L Raffington, Richard Karlsson Linnér, Philipp Koellinger, Abraham A Palmer and 6 more

Abstract read
In one paragraph

Article in Clinical psychological science : a journal of the Association for Psychological Science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. In praise of scientific open relationships: Commentary on Caspi et al. (2026).Journal of psychopathology and clinical science · 2026
    Article
  3. Personality Genomics.Annual review of psychology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Peter T TanksleyAdvanced Law Enforcement Rapid Response Training Center, Texas State University, San Marcos, TX, USA.
Sarah J BrislinDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Jasmin WertzDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
Ronald de VlamingDepartment of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Natasia S Courchesne-KrakDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Travis T MallardDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Laurel L RaffingtonMax Planck Research Group Biosocial - Biology, Social Disparities, and Development; Max Planck Institute for Human Development; Lentzeallee 94, 14195 Berlin, Germany.
Richard Karlsson LinnérDepartment of Economics, Leiden Law School, Leiden University, Leiden, the Netherlands.
Philipp KoellingerDepartment of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Irwin D WaldmanDepartment of Psychology, Emory University, Atlanta, GA, USA.
Danielle DickDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Terrie E MoffittDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Avshalom CaspiDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
K Paige HardenPopulation Research Center, The University of Texas at Austin, Austin, TX, USA.

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2014 to 2023
$27.4M
Training Program in Population StudiesT32HD007081 · NICHD · UNIVERSITY OF TEXAS AUSTIN · PI Aprile Dawn Benner, Abigail Mae Weitzman · 1985 to 2026
$6.8M
Interdisciplinary Research Fellowship in NeuroAIDSR25MH081482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIANA CHERNER · 2007 to 2026
$5.2M
Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI Catherine A Calder · 2017 to 2026
$5.2M
Using the Genetic Architecture of Substance Use Disorders to Advance Gene Identification and Understanding of Pathways of RiskR01DA050721 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DANIELLE M DICK · 2020 to 2026
$3.9M
Environmental, Genetic, and Epigenetic Mechanisms for Hormonal ChangeR01HD092548 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI HARDEN, KATHRYN PAIGE · 2019 to 2023
$3.0M
Neuropsychological and genomic signatures of violence exposure in childhoodR01HD077482 · NICHD · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2013 to 2018
$2.8M
Building Bridges to Allow Cross-species Translational genetics for the Study of AddictionDP1DA054394 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANCHEZ ROIGE, SANDRA · 2021 to 2025
$2.4M
NIAAA NIH HHS L40 AA031140NICHD NIH HHS P2C HD042849NICHD NIH HHS R01 HD077482NICHD NIH HHS R01 HD092548NICHD NIH HHS T32 HD007081NIDA NIH HHS DP1 DA054394NIDA NIH HHS P50 DA037844NIDA NIH HHS R01 DA050721NIMH NIH HHS R25 MH081482
6 · The paper itself

Abstract

Failures of self-control can manifest as externalizing behaviors (e.g., aggression, rule-breaking) that have far-reaching negative consequences. Researchers have long been interested in measuring children's genetic risk for externalizing behaviors to inform efforts at early identification and intervention. Drawing on data from the Environmental Risk Longitudinal Twin Study (

Indexed as

DevelopmentDirect Genetic EffectsExternalizingPolygenic IndexSelf-control

Identifiers

PMID40110515
PMCPMC11922333

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.