Evidence map›Paper›PMID 40110481›Full record

ArticleFrontiers in aging neuroscience2025

Role of right dorsolateral prefrontal cortex-left primary motor cortex interaction in motor inhibition in Parkinson's disease.

Zhen Wang, Jianing Wei, Yuyu Song, Yuting Li, Yin Wu, Robert Chen, Zhen Wang, Jian Zhang, Xiaoyin Tan, Ke Liu

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In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zhen WangSchool of Sport and Health Science, Xi'an Physical Education University, Xi'an, China.
Jianing WeiHenan University of Science and Technology Sports Institute, Luoyang, China.
Yuyu SongSchool of Psychology, Shanghai University of Sport, Shanghai, China.
Yuting LiSchool of Psychology, Shanghai University of Sport, Shanghai, China.
Yin WuSchool of Economics and Management, Shanghai University of Sport, Shanghai, China.
Robert ChenKrembil Research Institute, University Health Network, Toronto, ON, Canada.
Zhen WangSchool of Martial Arts, Shanghai University of Sport, Shanghai, China.
Jian ZhangSchool of Psychology, Shanghai University of Sport, Shanghai, China.
Xiaoyin TanFaculty of Health Sciences and Sports, Macao Polytechnic University, Macau, Macao SAR, China.
Ke LiuShanghai Punan Hospital of Pudong New District, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Impaired motor inhibition in Parkinson's disease (PD) is associated with functional alterations in the frontal-basal ganglia (BG) neural circuits. The right dorsolateral prefrontal cortex (DLPFC), pre-supplementary motor area (pre-SMA), and primary motor cortex (M1) play key roles in regulating this inhibition. However, the changes in interhemispheric interactions during motor inhibition in PD have not been clearly defined. Methods: We used dual-site paired-pulse transcranial magnetic stimulation (ppTMS) to examine the interactions between the right DLPFC and pre-SMA and the left M1 in 30 patients with early-stage PD and 30 age-matched healthy controls (HC) during both resting and active conditions, specifically while performing a stop-signal task (SST). Results: Stop-signal reaction times (SSRT) were significantly longer in PD patients compared to HC. The right DLPFC-left M1 interaction, at both short- and long-latency intervals, showed enhanced inhibition in PD following the stop-signal. In PD patients, SSRT was correlated with the inhibition of the right DLPFC-left M1 interaction, with stronger inhibition associated with shorter SSRT. Conclusion: The deficit in reactive inhibition observed in PD is linked to an abnormal modulation of the right DLPFC-left M1 interaction during the stopping process.

Indexed as

dorsolateral prefrontal cortexinterhemispheric interactionmotor inhibitionParkinson’s diseasepre-supplementary motor area

Identifiers

PMID40110481
PMCPMC11919838

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.