Evidence map›Paper›PMID 40110256›Full record

ArticleAnnals of medicine and surgery (2012)2025

Detecting ectopic thymus in thymoma-associated myasthenia gravis through flow cytometry analysis of CD3

Yongqiang Ao, Jie Deng, Jiahao Jiang, Min Yao, Jian Gao, Shuai Wang, Chun Jin, Qiuyue Liu, Yunze Zhai, Fengxue Du and 10 more

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In one paragraph

Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Yongqiang AoDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jie DengCAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Jiahao JiangDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Min YaoCAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Jian GaoDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Shuai WangDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Chun JinDepartment of Thoracic Surgery, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai, China.
Qiuyue LiuState Key Laboratory of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Yunze ZhaiState Key Laboratory of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Fengxue DuState Key Laboratory of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Yu ZhangCAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Juan ZhangCAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Yuejuan ZhengThe Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosecurity, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jiazi RenState Key Laboratory of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Zuoren YuState Key Laboratory of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Yunli ShenDepartment of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Aiwu KeCancer Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Yongbing CaoInstitute of Vascular Disease, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Haikun WangCAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Jianyong DingDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Traditional histological methods for identifying ectopic thymus (ET) have significant limitations including high risk of false negatives. This study aims to evaluate the effectiveness of flow cytometry in detecting ETs in patients undergoing total thymectomy. Methods: We analyzed 864 samples from 103 patients using flow cytometry and hematoxylin and eosin (H&E) staining. ETs were identified by the presence of CD3 Results: In the discovery set, flow cytometry detected ETs in 69.2% of samples, compared to 23.6% by histological methods. The validation set showed a higher incidence of ETs in myasthenia gravis (MG) patients than in non-MG patients (73.5% vs. 58.0%, Conclusions: Flow cytometry is a viable alternative for ET detection, providing a novel distribution map that enhances surgical decision-making in MG treatment.

Indexed as

distributionectopic thymusflow cytometryincidencemyasthenia gravisthymoma

Identifiers

PMID40110256
PMCPMC11918567

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