ArticleFrontiers in oncology2025
Long-term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation: a large-scale propensity score matching analysis.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Influential factors affecting the survival benefit of combined neoadjuvant therapy and esophagectomy in patients with esophageal cancer: an analysis based on the SEER database.Translational cancer research · 2025Article
- Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations.Frontiers in oncology · 2025Review
- Survival outcomes of intrathoracic vs. cervical anastomosis post-esophagectomy in middle and lower thoracic esophageal squamous cell carcinoma: a retrospective propensity score matching analysis.Frontiers in oncology · 2025Article
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10 authors.
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Abstract
Background: Esophagectomy is the primary treatment for localized esophageal squamous cell carcinoma (ESCC). Intraoperative thoracic duct ligation (TDL) has been suggested as an adjunct to reduce the risk of postoperative chylothorax in patients with ESCC, but its effect on long-term oncologic outcomes remains uncertain. Methods: Data from the Sichuan Cancer Hospital and Institute Esophageal Cancer Case Management Database were analyzed for patients treated between 2010 and 2017. Participants were classified into TDL and non-TDL groups. Univariate Cox regression analyses and propensity score matching (PSM) were used to identify independent risk factors for overall survival (OS). Results: A total of 2,510 patients were included, with 2,095 in the TDL group and 415 in the non-TDL group. The median follow-up was 63.97 months. No significant differences in OS were observed between the TDL and non-TDL groups (HR: 1.13; 95% CI: 0.96-1.31; P = 0.13). After PSM, the analysis continued to show no significant differences between the groups (P = 0.72). Conclusion: Intraoperative TDL during esophagectomy did not significantly impact long-term OS in patients with ESCC.
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