Evidence map›Paper›PMID 40110068›Full record

ArticleNeuro-oncology practice2025

Managing Cancer and Living Meaningfully in adults with brain metastases: A NIH ORBIT model phase II feasibility and proof-of-concept trial.

Ashlee R Loughan, Autumn Lanoye, Kelcie Willis, Sarah Ellen Braun, Alexandria Davies, Gary Rodin, Leroy Thacker, Amber Fox, Christopher Kleva, Giuliana Zarrella and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05087095 (Managing Distress in Malignant Brain Cancer), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05087095 nacompletednot on this map

Managing Distress in Malignant Brain Cancer

TypeinterventionalSponsorVirginia Commonwealth UniversityRan2022 to 2023Enrolled13ConditionsCancer Metastatic to Brain, Brain Metastases, AdultArmsCALM Intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ashlee R LoughanMassey Comprehensive Cancer Center, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0003-1231-2469
Autumn LanoyeMassey Comprehensive Cancer Center, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0003-3705-0880
Kelcie WillisDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Sarah Ellen BraunMassey Comprehensive Cancer Center, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-7184-0125
Alexandria DaviesMassey Comprehensive Cancer Center, Richmond, Virginia, USA.
Gary RodinPrincess Margaret Cancer Center, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-6626-6974
Leroy ThackerSchool of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Amber FoxDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
Christopher KlevaDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
Giuliana ZarrellaDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
Suzanne MazzeoDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
Dace SvikisDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
Leigh SwartzMcGuire Veterans Hospital, Richmond, Virginia, USA.

Funding

Wright Regional Center for Clinical and Translational ScienceUM1TR004360 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI FREDERICK Gerard MOELLER · 2023 to 2026
$16.3M
Training in Oncology Population Sciences (TOPS)T32CA092203 · NCI · DANA-FARBER CANCER INST · PI Nancy L Keating, JENNIFER W MACK · 2018 to 2026
$3.7M
NCATS NIH HHS UM1 TR004360NCI NIH HHS T32 CA092203
6 · The paper itself

Abstract

Background: Managing Cancer and Living Meaningfully (CALM) is a brief, evidence-based psychotherapy designed to help patients with advanced cancer cope with the practical and profound challenges of their illness. However, no study has systematically examined CALM in adults with brain metastases, despite the well-documented incidence of distress in this growing population. The primary aim of this trial was to assess the feasibility and acceptability of CALM in adults with brain metastases. Methods: Patients with brain metastases ( Results: Of the 13 enrolled participants, 11 completed baseline assessments and initiated treatment: 73% female, Conclusions: CALM is feasible and acceptable and may improve psychological distress in adults with brain metastases. The findings of this study align with our previous trial of patients with malignant glioma and support a future National Institute of Health Obesity Related Behavioral Intervention Trials phase II randomized pilot trial of CALM in neuro-oncology. Trial Registration Number: NCT05087095 registered on March 23, 2022.

Indexed as

acceptabilitybrain metastasesCALMdeath anxietydepressionfeasibilitypsychotherapy

Identifiers

PMID40110068
PMCPMC11913651

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.