Evidence map›Paper›PMID 40110044›Full record

ReviewFrontiers in genetics2025

Mechanism of action of lncRNA-NEAT1 in immune diseases.

Ruo-Xuan Zhang, Zi-Xuan Zhang, Xiang-Yu Zhao, Yi-Han Liu, Xiao-Meng Zhang, Qin Han, Xiao-Yu Wang

Abstract readReview
In one paragraph

Review in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Role of lncRNAs in pathophysiology of obesity.Current opinion in physiology · 2025
    Article
  8. Biology methods & protocols · 2025
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruo-Xuan Zhang *School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Zi-Xuan Zhang *School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Xiang-Yu ZhaoSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Yi-Han LiuSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Xiao-Meng ZhangSchool of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Qin HanSchool of Management, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Xiao-Yu WangSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NEAT1, a long non-coding RNA (lncRNA), is involved in assembling nuclear paraspeckles that have been found to impact various immune-related diseases, such as autoimmune diseases, allergic diseases, cancer immunity, sepsis, etc. In immune-related diseases, lncRNA-NEAT1 affects the activation, proliferation, and differentiation process of immune cells by interacting with transcription factors and miRNA (MicroRNA) to regulate an expression level in immune-related genes. It can also regulate the apoptosis and autophagy processes of immune cells by regulating inflammatory responses, interacting with apoptosis-related proteins, or regulating the expression of autophagy-related genes, thereby regulating the development of immune-related diseases. In recent years, a large number of researchers have found that the abnormal expression of lncRNA-NEAT1 has a great impact on the onset and progression of immune diseases, such as innate immunity after viral infection and the humoral immunity of T lymphocytes. In this paper, the specific mechanism of action and the function of lncRNA-NEAT1 in different immune-related diseases are sorted out and analyzed, to furnish a theoretical foundation for the study of the mechanism of action of immune cells.

Indexed as

action pathwaysallergic diseasesautoimmune diseasescancerimmune moleculesLncRNA-NEAT1

Identifiers

PMID40110044
PMCPMC11919857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.