Evidence map›Paper›PMID 40110027›Full record

ArticleFrontiers in cellular and infection microbiology2025

Optimized oxygen therapy improves sleep deprivation-induced cardiac dysfunction through gut microbiota.

Shuqi Cai, Zixuan Li, Jie Bai, Yue Ding, Ruisang Liu, Liben Fang, Dengyong Hou, Sheng Zhang, Xiaohui Wang, Yujia Wang and 6 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shuqi Cai *College of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
Zixuan Li *Naval Medical Center, Naval Medical University, Shanghai, China.
Jie Bai *Department of Pathogen Biology, Naval Medical University, Shanghai, China.
Yue Ding *Department of Pathogen Biology, Naval Medical University, Shanghai, China.
Ruisang LiuNaval Medical Center, Naval Medical University, Shanghai, China.
Liben FangNaval Medical Center, Naval Medical University, Shanghai, China.
Dengyong HouNaval Medical Center, Naval Medical University, Shanghai, China.
Sheng ZhangDepartment of Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaohui WangDepartment of Pathogen Biology, Naval Medical University, Shanghai, China.
Yujia WangDepartment of Pathogen Biology, Naval Medical University, Shanghai, China.
Yuyu JiangDepartment of Pathogen Biology, Naval Medical University, Shanghai, China.
Yan XiangDepartment of Pathogen Biology, Naval Medical University, Shanghai, China.
Wenhui WuCollege of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
Ying HeNaval Medical Center, Naval Medical University, Shanghai, China.
Yunkai ZhangNaval Medical Center, Naval Medical University, Shanghai, China.
Xiaomeng RenNaval Medical Center, Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adequate sleep is of paramount importance for relieving stress and restoring mental vigor. However, the adverse physiological and pathological responses resulting from sleep insufficiency or sleep deprivation (SD) are becoming increasingly prevalent. Currently, the impact of sleep deficiency on gut microbiota and microbiota-associated human diseases, especially cardiac diseases, remains controversial. Here, we employed the following methods: constructed an experimental sleep-deprivation model in mice; conducted 16S rRNA sequencing to investigate the changes in gut microbiota; through fecal microbiota transplantation (FMT) experiments, transplanted fecal microbiota from sleep-deprived mice to other mice; established an environment with a 30% oxygen concentration to explore the therapeutic effects of oxygen therapy on gut microbiota-associated cardiac fibrosis and dysfunction; and utilized transcriptome data to study the underlying mechanisms of oxygen therapy. The results revealed that: sleep-deprived mice exhibited weakness, depression-like behaviors, and dysfunction in multiple organs. Pathogenic cardiac hypertrophy and fibrosis occurred in sleep-deprived mice, accompanied by poor ejection fraction and fractional shortening. 16S rRNA sequencing indicated that sleep deprivation induced pathogenic effects on gut microbiota, and similar phenomena were also observed in mice that received fecal microbiota from sleep-deprived mice in the FMT experiments. The environment with a 30% oxygen concentration effectively alleviated the pathological impacts on cardiac function. Transcriptome data showed that oxygen therapy targeted several hypoxia-dependent pathways and inhibited the production of cardiac collagen. In conclusion, these results demonstrate the significance of sufficient sleep for gut microbiota and may represent a potential therapeutic strategy, where the oxygen environment exerts a protective effect on insomniacs through gut microbiota.

Indexed as

Gastrointestinal MicrobiomeHeart DiseasesOxygenSleep DeprivationAnimalsDisease Models, AnimalFecal Microbiota TransplantationFibrosisMaleMiceMice, Inbred C57BLRNA, Ribosomal, 16SOxygenRNA, Ribosomal, 16Scardiac dysfunctiongut microbiotahypoxiaoxygen therapysleep deprivation

Identifiers

PMID40110027
PMCPMC11919660

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.