Evidence map›Paper›PMID 40109953›Full record

ArticleCurrent opinion in physiology2022

Recent Insights Concerning Autophagy and Endothelial Cell Nitric Oxide Generation.

Seul-Ki Park, Jae Min Cho, Sohom Mookherjee, Paulo W Pires, J David Symons

Abstract read
In one paragraph

Article in Current opinion in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Seul-Ki ParkDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Jae Min ChoDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles.
Sohom MookherjeeDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Paulo W PiresDepartment of Physiology, University of Arizona College of Medicine, Tuscon.
J David SymonsDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.

Funding

Role of Endothelial K+ Channels in Age-Related DementiaR01AG073230 · NIA · LOMA LINDA UNIVERSITY · PI Erik J. Behringer, Paulo W Pires · 2022 to 2026
$3.3M
Autophagy and Arteriovenous Fistula MaturationR01HL153244 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEE, TIMMY C, SHIU, YAN-TING E. · 2021 to 2024
$2.2M
Autophagy maintains vascular function through a novel glycolysis-linked pathway regulating eNOS.R01HL141540 · NHLBI · UNIVERSITY OF UTAH · PI SYMONS, JOHN DAVID · 2018 to 2021
$1.7M
Cerebral functional hyperemia responses induced by capillary NMDA receptors are disrupted by amyloid-beta accumulationR00HL140106 · NHLBI · UNIVERSITY OF ARIZONA · PI PIRES, PAULO W · 2019 to 2021
$747k
Characterizing the phenotype of young and old mice with disrupted vascular autophagyR03AG052848 · NIA · UNIVERSITY OF UTAH · PI SYMONS, JOHN DAVID · 2017 to 2018
$152k
American Heart Association-American Stroke Association 20PRE35110066 - JAE MIN CHONHLBI NIH HHS R00 HL140106NHLBI NIH HHS R01 HL141540NHLBI NIH HHS R01 HL153244NIA NIH HHS R01 AG073230NIA NIH HHS R03 AG052848
6 · The paper itself

Abstract

Although endothelial cell (EC) dysfunction contributes to the etiology of more diseases than any other tissue in the body, EC metabolism is an understudied therapeutic target. Evidence regarding the important role of autophagy in maintaining EC homeostasis is accumulating rapidly. Here we focus on advances over the past two years regarding how EC autophagy mediates EC nitric oxide generation in the context of aging and cardiovascular complications including coronary artery disease, aneurysm, and stroke. In addition, insight concerning the efficacy of maneuvers designed to boost EC autophagy in an effort to combat cardiovascular complications associated with repressed EC autophagy is discussed.

Indexed as

Aginganeurysmatherosclerosiscoronary artery diseasestroke

Identifiers

PMID40109953
PMCPMC11922555

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.