Evidence map›Paper›PMID 40109907›Full record

ArticleFood chemistry: X2025

Machine learning analysis of pre-culture effects on rate-limiting steps in volatile compound dynamics of Mead.

Xian Li, Tiantian Zhang, Ziwei Liu, Meng Jiao, Qian Li, Martin Gand, Kexin Zhu, Yibing Qiao, Wushuang Bai, Zisheng Guo and 4 more

Abstract read
In one paragraph

Article in Food chemistry: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Unraveling flavor formation inFood chemistry: X · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xian LiCollege of Food Science and Engineering, Northwest University, Xi'an 710069, China.
Tiantian ZhangCollege of Petroleum and Chemical Engineering, Longdong University, Qingyang, Gansu 745000, China.
Ziwei LiuCollege of Food Science and Engineering, Northwest University, Xi'an 710069, China.
Meng JiaoKey Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province, the College of Life Sciences, Northwest University, Xi'an 710069, China.
Qian LiCollege of Food Science and Engineering, Northwest University, Xi'an 710069, China.
Martin GandInstitute of Food Chemistry and Food Biotechnology, Justus Liebig University Giessen, Giessen 35392, Germany.
Kexin ZhuCollege of Food Science and Engineering, Northwest University, Xi'an 710069, China.
Yibing QiaoCollege of Food Science and Engineering, Northwest University, Xi'an 710069, China.
Wushuang BaiCollege of Food Science and Engineering, Northwest University, Xi'an 710069, China.
Zisheng GuoKey Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province, the College of Life Sciences, Northwest University, Xi'an 710069, China.
Bin LiKey Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province, the College of Life Sciences, Northwest University, Xi'an 710069, China.
Yiran WangKey Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province, the College of Life Sciences, Northwest University, Xi'an 710069, China.
Jing DongKey Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province, the College of Life Sciences, Northwest University, Xi'an 710069, China.
Binglin LiCollege of Food Science and Engineering, Northwest University, Xi'an 710069, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel two-step fermentation process was developed to enhance mead flavor quality. Headspace Solid-Phase Microextraction Gas Chromatography-Mass Spectrometry (HS-SPME-GC-MS) with three columns was used to analyze the volatile profiles of meads, along with sensory evaluation and machine learning. Compared to traditional mead (TM), our novel mead (NM) reduced off-flavor compounds by 37.6 %, with isoamyl alcohol decreasing 1.26-fold and ethyl laurate 2.09-fold. Meanwhile, aromatic compounds increased by 39.41 %, with isoamyl acetate rising 3.31-fold, ethyl caproate 2.79-fold, and phenylethyl alcohol 1.69-fold. Sensory evaluation revealed a significant reduction in bitterness (41.1 %) and irritation (42.5 %), while fruity, sweet, and pleasantly sour flavors increased by 27.4 %, 36.9 %, and 45.5 % for NM. Key aroma compounds (benzaldehyde, 2,3-butanediol, cedrol) were identified via recombination and omission experiments. Dynamic monitoring and machine learning identified key rate-limiting steps, including the oxidation of benzeneacetaldehyde (phenylethyl alcohol synthesis), isovaleraldehyde (isoamyl alcohol synthesis), and the conversion of octanoic acid to decanoic acid.

Indexed as

2,3-Butanediol (PubChem CID: 262)3-Methylbutyl octanoate (PubChem CID: 5364423).Benzaldehyde (PubChem CID: 240)Benzeneacetaldehyde (PubChem CID: 9985)Cedrene (PubChem CID: 6431014)Ethyl caproate (PubChem CID: 31265)Isoamyl alcohol (PubChem CID: 31260)Machine learningMeadMetabolomicsNerolidol (PubChem CID: 5284507).Phenylethyl alcohol (PubChem CID: 6054)Rate-limiting stepSPMEtrans-Farnesol (PubChem CID: 445070)Volatile compounds

Identifiers

PMID40109907
PMCPMC11919604

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.