Evidence map›Paper›PMID 40109874›Full record

ArticleCurrent research in toxicology2025

Community-based insights into the connection between endocrine-disrupting chemicals and depressive symptoms.

Yun-An Liu, Heng-Jung Hsu, Heng-Chih Pan, Chiao-Yin Sun, Yih-Ting Chen, Chin-Chan Lee, Feng-Chieh Su, Yi-Chia Wei, Cheng-Kai Hsu, Chun-Yu Chen

Abstract read
In one paragraph

Article in Current research in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Unraveling the Core of Endometriosis: The Impact of Endocrine Disruptors.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yun-An LiuDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung Branch 222, Mai-Chin Road, Keelung 20401, Taiwan, Republic of China.
Heng-Jung HsuDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung Branch 222, Mai-Chin Road, Keelung 20401, Taiwan, Republic of China.
Heng-Chih PanDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung Branch 222, Mai-Chin Road, Keelung 20401, Taiwan, Republic of China.
Chiao-Yin SunDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung Branch 222, Mai-Chin Road, Keelung 20401, Taiwan, Republic of China.
Yih-Ting ChenDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung Branch 222, Mai-Chin Road, Keelung 20401, Taiwan, Republic of China.
Chin-Chan LeeDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung Branch 222, Mai-Chin Road, Keelung 20401, Taiwan, Republic of China.
Feng-Chieh SuCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yi-Chia WeiCommunity Medicine Research Center, Chang Gung Memorial Hospital, Keelung Branch 222, Mai-Chin Road, Keelung 20401, Taiwan, Republic of China.
Cheng-Kai HsuDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung Branch 222, Mai-Chin Road, Keelung 20401, Taiwan, Republic of China.
Chun-Yu ChenDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung Branch 222, Mai-Chin Road, Keelung 20401, Taiwan, Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The rising prevalence of depressive disorders has sparked concerns regarding environmental risk factors, particularly exposure to endocrine-disrupting chemicals (EDCs). However, the link between EDC exposure and depressive symptoms remains largely unexplored. Methods: The Chang Gung Community Medicine Research Center carried out a cross-sectional study across four regions in northeastern Taiwan. Out of 887 participants, 120 subjects were chosen according to their EDC exposure scores. These participants underwent urinary EDC analysis and were evaluated for depressive symptoms through the standardized Hospital Anxiety and Depression Scale - Depression subscale (HADS-D) questionnaire. Results: Participants with HADS-D scores ≥ 8 exhibited significantly higher EDC exposure score compared to those with lower scores. The correlation analyses identified a notible positive association between urinary monobenzyl phthalate (MBzP) levels and HADS-D scores ( Conclusion: Exposure to EDCs, particularly MBzP and MP, could be associated with a heightened risk of depressive symptoms.

Indexed as

Community medicineDepressive symptomsEndocrine-disrupting chemicalsEnvironmental hormoneParabenPhthalate

Identifiers

PMID40109874
PMCPMC11919602

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.