Evidence map›Paper›PMID 40109840›Full record

ArticleCureus2025

Extended Prodromal Period in Herpes Zoster: A Case Report and Management Implications.

Hidehiro Someko, Kazumori Takamoto, Yuki Kataoka

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hidehiro SomekoDepartment of Healthcare Epidemiology, Graduate School of Medicine, Kyoto University, Kyoto, JPN.
Kazumori TakamotoDepartment of Dermatology, National Hospital Organization Kyoto Medical Center, Kyoto, JPN.
Yuki KataokaDepartment of Internal Medicine, Kyoto Min-iren Asukai Hospital, Kyoto, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes zoster typically presents with a prodromal phase of pain lasting three to five days before the appearance of characteristic vesicular lesions. We report a case of herpes zoster in an immunocompetent man in his 70s who experienced an unusually prolonged prodromal period of two weeks. The patient initially presented with radicular pain in the right lower extremity, leading to evaluation for lumbar spinal stenosis. After the appearance of vesicular lesions in the L4-S1 dermatomes, he was diagnosed with herpes zoster and treated with valacyclovir and pregabalin. Despite the delayed initiation of therapy, the patient's symptoms resolved completely without recurrence. This case demonstrates that prolonged prodromal periods can occur in immunocompetent individuals and highlights the importance of maintaining clinical suspicion for herpes zoster in cases of persistent radicular pain. Although our patient recovered well despite treatment delay, prompt initiation of antiviral therapy is recommended once herpes zoster is clinically suspected to ensure optimal outcomes.

Indexed as

dermatomediagnostic and therapeutic challengeneuropathic pain treatmentvaricella-zoster viruszoster sine herpete radicular pain

Identifiers

PMID40109840
PMCPMC11919642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.