Evidence map›Paper›PMID 40109750›Full record

ArticleACS pharmacology & translational science2025

Anti-Inflammatory, Antihyperalgesic, and Gastric Safety Profiling of Ocimene: Attenuation of Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Ulcers by Modulating Toll-like Receptor 4 and Pyroptosis Pathways.

Iqra Laraib, Sumera Qasim, Ambreen Malik Uttra, Fakhria A Al-Joufi

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Essential Oil ofPlants (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Iqra LaraibDepartment of Pharmacology, College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
Sumera QasimDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Al-Jouf, Saudi Arabia.
Ambreen Malik UttraDepartment of Pharmacology, College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.ORCID https://orcid.org/0000-0002-4800-4882
Fakhria A Al-JoufiDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Al-Jouf, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monocyclic monoterpenoid ocimene (OC) was evaluated as a potential inhibitor of TLR4/NLRP3/GSDMD-driven pyroptosis, implicated in conditions such as chronic pain, inflammation, and gastric ulcers. This study investigated OC's protective effects against indomethacin (IND)-induced gastric ulcers, aiming to identify an analgesic and anti-inflammatory agent with enhanced gastric safety. OC's analgesic efficacy was demonstrated by reducing formalin-evoked paw licking, writhing provoked by acetic acid-induced and tail immersion reaction latencies in animal models. Anti-inflammatory effects were confirmed through reduced paw edema (formalin and carrageenan), along with

Identifiers

PMID40109750
PMCPMC11915039

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.