Evidence map›Paper›PMID 40109735›Full record

ArticleACS pharmacology & translational science2025

Aleksandra Leszczynska, Thibault Alle, Benedikt Kaufmann, Hana Sung, Christian Stoess, Agustina Reca, Andrea Kim, Sun Kim, Chelsea Tran, Killian Oukoloff and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Aleksandra LeszczynskaDepartment of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Thibault AlleSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0001-8459-6443
Benedikt KaufmannDepartment of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Hana SungDepartment of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Christian StoessDepartment of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Agustina RecaDepartment of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Andrea KimDepartment of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Sun KimDepartment of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Chelsea TranDepartment of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Killian OukoloffSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Ludovica MontiSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Bobby LuceroSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Ilya GertsmanClarus Analytical LLC, 8545 Arjons Dr. Suite A, San Diego, California 92126, United States.
Jeremiah D MomperSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Phillipp HartmannDepartment of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Ariel E FeldsteinDepartment of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Ranjan DohilDepartment of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Carlo BallatoreSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0002-2718-3850

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial chronic disease that can progress to metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis, ultimately leading to liver cirrhosis and hepatocellular carcinoma. Oxidative stress is believed to play an important role in the development of MASH. Small aminothiol compounds such as cysteamine and its oxidized precursor, cystamine, are known pleiotropic compounds that exhibit relatively potent antioxidant and other effects. Herein, we evaluate the efficacy of cystamine, as well as two deuterated derivatives, in a choline-deficient, L-amino acid-defined, high-fat-diet (CDAA-HFD) mouse model of rapidly progressing liver fibrosis. Compared to control mice, daily oral administration of isotopically reinforced cystamine derivatives (200 mg/kg) led to a significant reduction of liver fibrosis and inflammation as well as oxidative stress. Moreover, the efficacy of treatment appeared to increase with the deuteration state of cystamine, with the tetradeuterated derivative,

Identifiers

PMID40109735
PMCPMC11915185

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.