ArticleAnnals of medicine and surgery (2012)2025
Brain tumors and induced pluripotent stem cell technology: a systematic review of the literature.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Safety and toxicity assessment of antisense oligonucleotides in brain-relevant human cellular models.Molecular therapy. Nucleic acids · 2026Review
- Modeling pediatric brain tumors with human stem cells.Frontiers in cellular neuroscience · 2026Review
- Advancing Medulloblastoma Treatment: Molecular Mechanisms, Drug Repurposing, and Precision Therapies.Molecular diagnosis & therapy · 2026Review
- Keratan Sulfate Is a Multifunctional Brain Glycosaminoglycan With Instructive Capabilities.Journal of neurochemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Induced pluripotent stem cells (iPSCs) provide a novel approach to studying the pathophysiology of brain tumors and assessing various therapeutic techniques with greater precision. This study aims to systematically review the existing literature to critically analyze and synthesize current research findings. The objective is to evaluate the role of iPSCs in understanding brain tumors and in the development of innovative treatment strategies. Methods: We systematically reviewed existing articles that utilized iPSC technology to assess either the pathophysiology of brain tumors or therapeutic techniques, following the standards of Preferred Reporting Items for Systematic review and Meta-Analysis guidelines. Key terms were comprehensively searched in electronic databases, including PubMed, EMBASE, and Scopus. Articles were screened based on specific inclusion and exclusion criteria. Ultimately, 22 relevant articles were chosen, and their data were extracted. Results: The summary of findings for each selected article was organized into two general categories: "Methods of Generating iPSCs" and "Applications of iPSCs." The methods of iPSC generation, including transfection and transduction, as well as the types of viral or non-viral vectors used, were extracted and reported for each study. Additionally, the main aims of the selected studies, whether modeling or therapeutic approaches, were gathered and reported in the results section. Conclusion: iPSC technology is a novel vehicle that brings new solutions to overcome difficulties in brain tumor studies. In vivo and in vitro models generated from iPSCs provide suitable platforms to investigate the pathophysiology of brain tumors more precisely. Also, iPSCs have been utilized in various studies to examine how different antitumor agents may affect the target cells.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.