Evidence map›Paper›PMID 40109570›Full record

ArticlePediatric gastroenterology, hepatology & nutrition2025

Difference in Cow's Milk-Related Symptom Score (CoMiSS

Nienke Knockaert, Koen Huysentruyt, Badriul Hegar, Jackeline Motta Franco, Victor Ravel Santos Macedo, Sarah Cristina Fontes Vieira, Yvan Vandenplas

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In one paragraph

Article in Pediatric gastroenterology, hepatology & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nienke KnockaertKidZ Health Castle, UZ Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID https://orcid.org/0009-0000-8507-6802
Koen HuysentruytKidZ Health Castle, UZ Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID https://orcid.org/0000-0002-6402-1762
Badriul HegarDepartment of Child Health, Faculty Medicine Universitas Indonesia, Jakarta, Indonesia.ORCID https://orcid.org/0000-0002-5924-1664
Jackeline Motta FrancoReference Center for Food Allergies of Sergipe, Federal University of Sergipe, Sergipe, Brazil.ORCID https://orcid.org/0000-0003-3088-492X
Victor Ravel Santos MacedoDepartment of Medicine, Federal University of Sergipe, Sergipe, Brazil.ORCID https://orcid.org/0000-0002-6483-0797
Sarah Cristina Fontes VieiraReference Center for Food Allergies of Sergipe, Federal University of Sergipe, Sergipe, Brazil.ORCID https://orcid.org/0000-0002-0830-9657
Yvan VandenplasKidZ Health Castle, UZ Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID https://orcid.org/0000-0002-1862-8651

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The Cow's Milk-related Symptom Score (CoMiSS) improves the recognition of cow milk allergy (CMA) symptoms. A score of ≥10 should raise awareness of CMA. The median CoMiSS in healthy European infants aged <6 months is 3. This study aimed to determine the impact of different regions on CoMiSS in healthy infants aged <12 months to evaluate regional and age-related differences. Methods: A prospective cross-sectional study was conducted at one hospital each in Indonesia (Jakarta) and Brazil (Sergipe). CoMiSS was assessed in healthy infants aged -12 months old. Results: In Jakarta, a total of 286 infants (50.7% boys) were included. The median (interquartile range) CoMiSS was 1.5 (0-4); the 95th percentile was 7. In Sergipe, 101 infants (60.4% boys) were included. The median (interquartile range) CoMiSS was 4 (4-6); the 95th centile was 10.9. Age (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.94-0.99; Conclusion: Median CoMiSS in healthy infants differed between Jakarta and Sergipe (1.5 vs. 4.0). These findings highlight that the perceived normality of parents may be region-dependent.

Indexed as

Cow’s Milk-related Symptom ScoreHealthy infantInfant colicRegurgitationStool consistency

Identifiers

PMID40109570
PMCPMC11919533

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.