Evidence map›Paper›PMID 40109544›Full record

ArticleBiomedical optics express2025

Exploiting the detector distance information in image scanning microscopy by phasor-based SPLIT-ISM.

Elisabetta Di Franco, Giulia Tedeschi, Lorenzo Scipioni, Enrico Gratton, Michelle Digman, Marco Castello, Alberto Diaspro, Giuseppe Vicidomini, Paolo Bianchini, Luca Lanzanò

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elisabetta Di FrancoDepartment of Physics and Astronomy "Ettore Majorana", University of Catania, Catania, Italy.
Giulia TedeschiLaboratory for Fluorescence Dynamics, University of California, Irvine, USA.
Lorenzo ScipioniLaboratory for Fluorescence Dynamics, University of California, Irvine, USA.
Enrico GrattonLaboratory for Fluorescence Dynamics, University of California, Irvine, USA.ORCID https://orcid.org/0000-0002-6450-7391
Michelle DigmanLaboratory for Fluorescence Dynamics, University of California, Irvine, USA.
Marco CastelloR&D Department, Genoa Instruments S.r.l., Via E. Melen 83, 16152 Genova, Italy.
Alberto DiasproNanoscopy, CHT Erzelli, Istituto Italiano di Tecnologia, Genoa, Italy.ORCID https://orcid.org/0000-0002-4916-5928
Giuseppe VicidominiMolecular Microscopy and Spectroscopy, CHT Erzelli, Istituto Italiano di Tecnologia, Genoa, Italy.ORCID https://orcid.org/0000-0002-3085-730X
Paolo BianchiniNanoscopy, CHT Erzelli, Istituto Italiano di Tecnologia, Genoa, Italy.ORCID https://orcid.org/0000-0001-6457-751X
Luca LanzanòDepartment of Physics and Astronomy "Ettore Majorana", University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0001-6539-394X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Confocal microscopy is an important bio-imaging technique that increases the resolution using a spatial pinhole to block out-of-focus light. In theory, the maximum resolution and optical sectioning are obtained when the detection pinhole is fully closed, but this is prevented by the dramatic decrease in the signal reaching the detector. In image scanning microscopy (ISM) this limitation is overcome by the use of an array of point detectors rather than a single detector. This, combined with pixel reassignment, increases the resolution of

Identifiers

PMID40109544
PMCPMC11919353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.