Evidence map›Paper›PMID 40109448›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Gandou Bushen Decoction Ameliorates Cognitive Impairment in Wilson Disease Model TX Mice by Regulating Melatonin Synthesis via the SIRT3/FOXO3α Pathway].

Luyao Wang, Limin Wu, Tingting Wang, Xinru Fang, Zhenzhen Jiang, Yike Yue, Dan Zhao, Qianzhuo Liu, Hui Han

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [ModifiedNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  2. [Gandou Bushen decoction ameliorates ovarian injury in murine hepatolenticular degeneration via the AGE/RAGE/NF-κB signaling pathway].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luyao Wang（ 230031） The First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Limin Wu（ 230031） The First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Tingting Wang（ 230031） The First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Xinru Fang（ 230031） The First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Zhenzhen Jiang（ 230031） The First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Yike Yue（ 230031） The First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Dan Zhao（ 230031） The First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Qianzhuo Liu（ 230031） The First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Hui Han（ 230031） The First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Melatonin has been shown to have neuroprotective effects. This study is aimed at observing the effects of copper deposition on cognitive function in a toxic milk (TX) mouse model of Wilson disease (WD), and investigating the effects and mechanisms of action of Gandou Bushen Decoction (GDBSD) on melatonin synthesis and pineal function in the WD model mice. Methods: A total of 30 homozygous TX mice were randomly assigned to 3 groups ( Results: Compared with the NC group, the WD group exhibited decreased learning and cognitive abilities ( Conclusion: GDBSD can alleviate cognitive impairments in WD mice caused by pineal gland copper deposition by inhibiting oxidative stress and apoptosis in the pineal gland. The underlying molecular mechanism is associated with the regulation of the SIRT3/FOXO3α signaling pathway.

Indexed as

Cognitive DysfunctionDrugs, Chinese HerbalForkhead Box Protein O3Hepatolenticular DegenerationMelatoninSirtuin 3AnimalsApoptosisCopperDisease Models, AnimalMaleMiceOxidative StressPineal GlandSignal TransductionCopperDrugs, Chinese HerbalForkhead Box Protein O3FoxO3 protein, mouseMelatoninSirt3 protein, mouseSirtuin 3Cognitive impairmentGandou Bushen DecoctionMelatoninPineal glandWilson disease

Identifiers

PMID40109448
PMCPMC11914004

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.