Evidence map›Paper›PMID 40109344›Full record

ArticleFrontiers in immunology2025

Immune mediators as plasma biomarkers for identifying household contacts and classifying clinical forms and leprosy reactions.

Jairo Campos Carvalho, Marcelo Antônio Pascoal-Xavier, Marcelo Grossi Araújo, Júlia Pereira Martins, Andrea Teixeira-Carvalho, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Vanessa Peruhype-Magalhães, Jordana Grazziela Alves Coelho-Dos-Reis, Olindo Assis Martins-Filho and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jairo Campos CarvalhoInstituto René Rachou/FIOCRUZ, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, Minas Gerais, Brazil.
Marcelo Antônio Pascoal-XavierInstituto René Rachou/FIOCRUZ, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, Minas Gerais, Brazil.
Marcelo Grossi AraújoUniversidade Federal de Minas Gerais, Serviço de Dermatologia do Hospital das Clínicas, Belo Horizonte, Minas Gerais, Brazil.
Júlia Pereira MartinsInstituto René Rachou/FIOCRUZ, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, Minas Gerais, Brazil.
Andrea Teixeira-CarvalhoInstituto René Rachou/FIOCRUZ, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, Minas Gerais, Brazil.
Matheus de Souza GomesLaboratório de Bioinformática e Análises Moleculares, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
Laurence Rodrigues AmaralLaboratório de Bioinformática e Análises Moleculares, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
Vanessa Peruhype-MagalhãesInstituto René Rachou/FIOCRUZ, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, Minas Gerais, Brazil.
Jordana Grazziela Alves Coelho-Dos-ReisUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Virologia Básica e Aplicada, Belo Horizonte, Minas Gerais, Brazil.
Olindo Assis Martins-FilhoInstituto René Rachou/FIOCRUZ, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, Minas Gerais, Brazil.
Márcio Sobreira Silva AraújoInstituto René Rachou/FIOCRUZ, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, Minas Gerais, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to evaluate the performance of plasma immune mediators in classifying leprosy patients [L(PB) and L(MB), paucibacillary and multibacillary leprosy, respectively], leprosy reaction patients (T1LR and T2LR, type 1 and type 2 leprosy reaction, respectively), household contacts (HHC), and non-infected (NI) controls. Quantitative measurements of these immune mediators were carried out using high-throughput multiplex microbead array. The results demonstrated that most of the plasma immune mediators were increased in all clinical groups compared with NI controls. Higher frequencies but lower maximum magnitudes of increase (fold change according to NI) were observed for T1LR (63%, 6.1×) and T2LR (63%, 9.7×) compared with HHC (48%, 68.5×), L(PB) (56%, 8.5×), and L(MB) (48%, 37.9×). The bi-dimensional scattering profiles (magnitude order

Indexed as

BiomarkersLeprosyAdolescentAdultAgedContact TracingCytokinesFamily CharacteristicsFemaleHumansMaleMiddle AgedMycobacterium lepraeYoung AdultBiomarkersCytokineschemokinescytokinedecision tree algorithmleprosyLuminex

Identifiers

PMID40109344
PMCPMC11920121

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.