Evidence map›Paper›PMID 40109326›Full record

ArticleDrug target insights

Exploring the in vitro anti-diabetic potential and in silico studies of 2, 3 and 2, 6-dichloroIndolinone.

Abdur Rauf, Waqas Alam, Momin Khan, Hany W Darwish, Maria Daglia, Ahmed A Elhenawy, Haroon Khan

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In one paragraph

Article in Drug target insights. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abdur RaufDepartment of Pharmacy, Abdul Wali Khan University, Mardan - Pakistan.ORCID https://orcid.org/0009-0009-4680-4956
Waqas AlamDepartment of Pharmacy, Abdul Wali Khan University, Mardan - Pakistan.ORCID https://orcid.org/0009-0009-4680-4956
Momin KhanDepartment of Chemistry, Abdul Wali Khan University, Mardan - Pakistan.
Hany W DarwishDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh - Kingdom of Saudi Arabia.
Maria DagliaDepartment of Pharmacy, University of Naples Federico II- Italy.ORCID https://orcid.org/0009-0009-4680-4956
Ahmed A ElhenawyDepartment of Chemistry, Faculty of Science, Al-Azhar University, Cairo - Egypt.ORCID https://orcid.org/0009-0009-4680-4956
Haroon KhanDepartment of Pharmacy, Abdul Wali Khan University, Mardan - Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Adequate hyperglycemic control is still a huge challenge with the clinically used therapeutics. New, more effective anti-diabetic agents are on the top list of drug discovery projects. Methods: This article deals with the in vitro anti-diabetic potential of 2, 3 dichloroIndolinone (C1) and 2, 6-dichloroIndolinone (C2) on α-glucosidase and α-amylase followed by in silico analysis. Results: Both compounds, C-1 and C-2, caused significant inhibition of α-glucosidase at various test concentrations with IC Conclusion: In short, this study will contribute to providing these compounds with an improved anti-diabetic profile and decreased toxicity.

Indexed as

23 and 26-dichloroIndolinoneMolecular dockingMolecular simulationα-glucosidase/α-amylase inhibition

Identifiers

PMID40109326
PMCPMC11920718

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.