Evidence map›Paper›PMID 40109120›Full record

ArticleThe FEBS journal2025

The complete absence of cytoplasmic γ-actin results in no discernible phenotype in mice or primary fibroblasts.

Lauren J Sundby, Katelin M Hawbaker, Jacob Powers, William M Southern, Erynn E Johnson, Xiaobai Patrinostro, Benjamin J Perrin, James M Ervasti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lauren J SundbyProgram in Molecular, Cellular, Developmental Biology, and Genetics, University of Minnesota, Minneapolis, MN, USA.
Katelin M HawbakerDepartment of Biology, Indiana University - Indianapolis, Indianapolis, IN, USA.
Jacob PowersDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
William M SouthernDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Erynn E JohnsonDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Xiaobai PatrinostroDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Benjamin J PerrinDepartment of Biology, Indiana University - Indianapolis, Indianapolis, IN, USA.
James M ErvastiDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-8259-5236

Funding

TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3M
Costamere Defects in Muscular DystrophiesR01AR049899 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI ERVASTI, JAMES M · 2005 to 2025
$8.2M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
Cytoskeletal stability in stereocilia maintenanceR01DC015495 · NIDCD · INDIANA UNIVERSITY INDIANAPOLIS · PI BENJAMIN J PERRIN · 2017 to 2026
$3.9M
NIAMS NIH HHS R01 AR049899NIAMS NIH HHS T32 AR007612NIA NIH HHS T32 AG029796NIDCD NIH HHS R01 DC015495NIH HHS R01-AR049899NIH HHS R01-DC015495NIH HHS T32-AG029796
6 · The paper itself

Abstract

Mice and primary fibroblasts derived from mouse embryos completely lacking cytoplasmic β-actin, because the Actb gene was engineered to instead express γ-actin protein, have previously been found to be virtually devoid of phenotype. Here, we report the characterization of mice and mouse embryonic fibroblasts homozygous for an Actg1 allele edited to translate β-actin instead of γ-actin (Actg1-coding beta; Actg1

Indexed as

ActinsCytoplasmFibroblastsAnimalsCell MovementCell ProliferationCells, CulturedEmbryo, MammalianMiceMuscle ContractionPhenotypeActinsActg1actinstereociliaγ‐actin

Identifiers

PMID40109120
PMCPMC12220839

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.