ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Interactions between menopause and high-fat diet on cognition and pathology in a mouse model of Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- ZBP1-mediated Treg cell dysfunction exacerbates neuroimmune dysregulation in Alzheimer's disease under metabolic stress.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sex specific effects of a high fat diet on metabolism, cognition, and pathology in the Tg-SwDI mouse model of Alzheimer's disease.Journal of neuroinflammation · 2026Article
- Surgical removal of visceral adipose tissue has therapeutic benefit in male APPFrontiers in endocrinology · 2026Article
- Loss of ovarian hormones is detrimental in early disease stages of mouse models of Alzheimer's disease and multi-etiology dementia.Biology of sex differences · 2025Article
- Sex Specific Effects of a High Fat Diet on Metabolism, Cognition, and Pathology in the Tg-SwDI Mouse Model of Alzheimer's Disease.Research square · 2025Article
- Interactions between menopause and high-fat diet on cognition and pathology in a mouse model of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
14 authors.
Funding
Abstract
introductionPost-menopausal women constitute about two-thirds of those with Alzheimer's disease (AD). Menopause increases dementia risk by heightening the likelihood of metabolic disease, a well-known risk factor for dementia. We aimed to determine the effects of menopause and high-fat diet (HF) on cognitive and pathological outcomes in an AD mouse model.
methodsAt 3 months old, App
resultsAn interaction between HF diet and menopause led to impaired recognition memory. No effects of menopause were observed on amyloid pathology. However, menopause induced alterations in microglial response, white matter, and hippocampal neurogenesis. DISCUSSION: This work highlights the need to model endocrine aging in animal models of dementia and contributes to further understanding of the interaction between menopause and metabolic health in the context of AD. HIGHLIGHTS: The combination of menopause and HF diet led to early onset of cognitive impairment. HF diet increased amyloid pathology in the hippocampus. Menopause led to an increase in microglia density and a decrease in myelin in the corpus callosum. Menopause altered hippocampal neurogenesis in a diet-dependent manner.
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