Evidence map›Paper›PMID 40108824›Full record

ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2025

Alpha-Gal Sensitization Dynamics in Individuals After Tick Bites With or Without Erythema Migrans.

Tamara van Gorkom, Michiel Heron, Agnetha Hofhuis, Carlijn Jongerius, Fiona R M van der Klis, Hanneke N G Oude Elberink, Hein Sprong, Steven F T Thijsen, Kristin Kremer

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In one paragraph

Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tamara van GorkomDepartment of Medical Microbiology and Immunology, Diakonessenhuis Hospital, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0002-1565-5902
Michiel HeronDepartment of Medical Microbiology and Immunology, Diakonessenhuis Hospital, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0003-0576-8652
Agnetha HofhuisCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Carlijn JongeriusDepartment of Medical Microbiology and Immunology, Diakonessenhuis Hospital, Utrecht, the Netherlands.
Fiona R M van der KlisCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Hanneke N G Oude ElberinkDepartment of Internal Medicine, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
Hein SprongCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Steven F T ThijsenDepartment of Medical Microbiology and Immunology, Diakonessenhuis Hospital, Utrecht, the Netherlands.
Kristin KremerCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Funding

Ministry of Health, Welfare and Sport of the Netherlands
6 · The paper itself

Abstract

α-Gal syndrome (AGS) is an emerging tick-borne disease characterised by the development of specific immunoglobulin E (sIgE) antibodies against galactose-α-1,3-galactose (α-gal), a carbohydrate found in most mammalian species, but not in humans. AGS occurs in individuals with a history of tick bites. Currently, no data exist on α-gal sIgE seroprevalence in the Dutch population, including those with tick bites or erythema migrans (EM). Therefore, this study aimed to determine the rate of α-gal sIgE seroprevalence in the Dutch population, to assess α-gal sIgE seroconversion after tick bites, and to determine the relationship between EM and α-gal sIgE in serum. α-Gal sensitisation rates were assessed in individuals with tick bites (TB), EM, and the general population. Blood samples were collected from TB- and EM-cases at baseline and again after 3 months. Single blood samples from controls were selected from a Dutch population survey. In total, 156 TB-cases, 160 EM-cases, and 316 population controls were included. α-Gal sensitisation rates were 1.9% for population controls and 10.3% and 19.1% for TB- and EM-cases at baseline, respectively (cut-off α-gal sIgE:  ≥ 0.10 kU

Indexed as

AllergensErythema Chronicum MigransTick BitesAdolescentAdultAgedAnimalsChildFemaleHumansImmunoglobulin EMaleMiddle AgedNetherlandsSeroepidemiologic StudiesYoung AdultAllergensImmunoglobulin Eallergens and epitopesclinical immunologyerythema migransfood allergygalactose‐α‐1,3‐galactoseIgEimmunologic teststick biteα‐gal sensitizationα‐gal syndrome

Identifiers

PMID40108824
PMCPMC11994249

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.