ArticleKnee surgery & related research2025
The impact of central sensitization on perioperative pain in TKA: a retrospective cohort study.
Article in Knee surgery & related research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Metformin Use Is Associated With Reduced Inflammation and Pain After Total Knee Arthroplasty in Patients With Type 2 Diabetes.Orthopaedic surgery · 2026Article
- Pain Phenotypes in Knee Osteoarthritis: Between Mechanistic Taxonomy and Clinical Complexity.Orthopaedic surgery · 2026Article
- Review
- Arthroscopic Arthrolysis of the Knee Joint Following Total Knee Arthroplasty.Journal of clinical medicine · 2025Article
- Pain in the Forecast: Investigating Weather Sensitivity Before and After Total Knee Arthroplasty.Life (Basel, Switzerland) · 2025Article
- Relationship between brain metabolites and chronic pain mechanisms in knee osteoarthritis pre- and post-total knee replacement.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundTotal knee arthroplasty (TKA) is an established surgical procedure for severe knee osteoarthritis (KOA) that has provided excellent outcomes. While several studies have reported that patients with preoperative central sensitization (CS) experienced worse pre- and post-operative pain and outcomes, the evidence is limited. We conducted this study to determine the impact of CS on perioperative knee pain in TKA for severe KOA.
methodsA retrospective cohort study of 66 patients who underwent bilateral TKA for bilateral severe KOA was conducted. Multiple linear regression models that included covariates and scaled estimated regression coefficients were used to examine the impact of CS on the patients' pre- and post-operative pain subscale values on the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the improvement of KOOS pain. Postoperative KOOS pain was assessed at 3 months postoperatively, while other evaluation items including preoperative KOOS pain, CS, and pain self-efficacy were assessed on admission.
resultsCS had a negative impact on pre- and post-operative KOOS pain (preoperative, β: -0.28, 95% confidence interval [CI] -18.53, -0.92; postoperative, β: -0.26, 95%CI -14.09, -0.44; p < 0.05). High pain self-efficacy had a positive impact on preoperative KOOS pain (β: 0.25, 95%CI 0.32, 18.08; p < 0.05). However, CS did not influence the improvement of KOOS pain.
conclusionsThese results demonstrate that CS had a negative impact on pre- and post-TKA knee pain in patients but did not affect the improvement of knee pain. TKA provides sufficient pain relief for severe KOA, with or without CS. Further research is required to improve pre- and post-operative knee pain in KOA patients with CS.
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