Evidence map›Paper›PMID 40108733›Full record

ArticleVeterinary research2025

Conserved function of bat IRF7 in activating antiviral innate immunity: insights into the innate immune response in bats.

Jie Wang, Qiuju Liu, Caixia Xu, Feiyu Fu, Qi Shao, Yapeng Fu, Zhaofei Wang, Jingjiao Ma, Hengan Wang, Yaxian Yan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Frontiers in immunology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jie Wang *Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Qiuju Liu *Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Caixia XuShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Feiyu FuShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Qi ShaoShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Yapeng FuShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Zhaofei WangShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Jingjiao MaShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Hengan WangShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Yaxian YanShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Jianhe SunShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China. sunjhe@sjtu.edu.cn.
Yuqiang ChengShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China. 1987lccyq@163.com.ORCID http://orcid.org/0000-0003-3388-1775

Funding

Interdisciplinary Program of Shanghai Jiao Tong University YG2021QN108National Natural Science Foundation of China 32072864National Natural Science Foundation of China 32072865
6 · The paper itself

Abstract

Bats are natural hosts for various highly pathogenic viruses, which pose a considerable threat to humans and animals. However, they rarely display signs of disease infection from these viruses. The expression of IRF7-induced IFN-β plays a crucial role in preventing viral infections. However, the role of bat IRF7 during viral infection remains unclear. In this study, we cloned Tadarida brasiliensis IRF7 and discovered that its amino acid sequence was poorly conserved among species. Next, we investigated the expression of bat IRF7 mRNA in Tadarida brasiliensis lung cells (TB 1 Lu) infected with RNA viruses such as Newcastle disease virus (NDV), avian influenza virus (AIV), vesicular stomatitis virus (VSV), and the double-stranded RNA (dsRNA) analogue poly (I:C) and demonstrated that these viral infections significantly upregulated the mRNA expression of bat IRF7. Furthermore, the overexpression of IRF7 in TB1 Lu cells activated the expression of bat innate immune-related genes and inhibited virus replication. Importantly, we observed that bat IRF7 function is highly conserved in avian and mammalian species. Structurally, we revealed that the IRF domain of bat IRF7 is essential for activating IFN-β. In summary, our findings indicate that bat IRF7 has a conserved ability to activate bat antiviral innate immunity. This study provides a theoretical foundation for further understanding the innate immune response in bats.

Indexed as

ChiropteraImmunity, InnateInterferon Regulatory Factor-7RNA Virus InfectionsAmino Acid SequenceAnimalsNewcastle disease virusInterferon Regulatory Factor-7BatIFN-βinnate immunityIRF7virus

Identifiers

PMID40108733
PMCPMC11921751

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.