Evidence map›Paper›PMID 40108726›Full record

ArticleJournal of medical case reports2025

Salivary gland adenoid cystic carcinoma presenting as a large metastatic hepatic mass: a case report.

Matthew Walker, Alisa Dewald, Abdelrhman Refaey, Ivan Berezowski, Jacob Newman, Mamoun Younes, Stephen Gray

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Matthew WalkerThe George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Alisa DewaldThe George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Abdelrhman RefaeyThe George Washington Transplant Institute, Department of Surgery, The George Washington University Hospital, Washington, DC, USA.
Ivan BerezowskiDepartment of Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Jacob NewmanDivision of Gastroenterology, Department of Medicine, Allegheny Health Network, Pittsburgh, PA, USA.
Mamoun YounesDepartment of Pathology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Stephen GrayThe George Washington Transplant Institute, Department of Surgery, The George Washington University Hospital, Washington, DC, USA. stgray@mfa.gwu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSalivary gland tumors are rare, representing 6-8% of head and neck tumors. Adenoid cystic carcinoma represents approximately 10% of salivary gland tumors. The preferential sites of metastases are the lung and bone, followed by the brain and liver. Liver metastasis as the initial clinical manifestation of parotid gland adenoid cystic carcinoma is very rare. CASE PRESENTATION: We report the case of a 29-year-old African American male patient with a metastatic salivary gland tumor who presented initially with a large hepatic mass. He complained of right upper quadrant pain and early satiety. Abdominal computed tomography revealed hepatomegaly with a large mass centered in the left lobe measuring 14 cm. A computed tomography scan revealed innumerable bilateral pulmonary nodules measuring up to 8 mm, favoring metastases. Initial histopathological examination of the liver biopsy specimens revealed a well-differentiated carcinoma characterized by a distinctive myxoid stroma, consistent with metastatic adenoid cystic carcinoma. The patient underwent transcatheter arterial chemoembolization and was discharged with a hematology-oncology follow-up. A presumptive diagnosis of stage IV adenoid cystic carcinoma with lung and liver metastases was made. The patient was given cisplatin and vinorelbine.

conclusionMetastatic parotid gland adenoid cystic carcinoma with initial clinical manifestation as a liver mass is very rare and was pathologically confirmed in this patient by its histological appearance. This case emphasizes the need for clinicians to consider salivary gland tumors in the differential diagnosis of unexplained hepatic lesions.

Indexed as

Carcinoma, Adenoid CysticLiver NeoplasmsParotid NeoplasmsSalivary Gland NeoplasmsAdultChemoembolization, TherapeuticDiagnosis, DifferentialHumansLung NeoplasmsMaleTomography, X-Ray ComputedAdenoid cystic carcinomaBasal cell adenocarcinomaCase reportCytopathologyLiver metastasisLung metastasisSalivary gland tumor

Identifiers

PMID40108726
PMCPMC11921573

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