Evidence map›Paper›PMID 40108720›Full record

ArticleArthritis research & therapy2025

The needed daily dose of colchicine in patients with Familial Mediterranean Fever may be higher in women: a study on behalf of the JIR cohort.

Ilenia Di Cola, Alessandra Bartoli, Léa Savey, Fatima Bensalek, Marion Delplanque, Rim Bourguiba, Zohra Aknouche, Isabelle Kone-Paut, Linda Rossi-Semerano, Isabelle Melki and 8 more

Abstract readLetter
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Article in Arthritis research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Ilenia Di ColaInternal Medicine Department, Tenon Hospital, AP-HP, Paris, France.
Alessandra BartoliInternal Medicine Department, Tenon Hospital, AP-HP, Paris, France.
Léa SaveyInternal Medicine Department, Tenon Hospital, AP-HP, Paris, France.
Fatima BensalekInternal Medicine Department, Tenon Hospital, AP-HP, Paris, France.
Marion DelplanqueInternal Medicine Department, Tenon Hospital, AP-HP, Paris, France.
Rim BourguibaInternal Medicine Department, Tenon Hospital, AP-HP, Paris, France.
Zohra AknoucheInternal Medicine Department, Tenon Hospital, AP-HP, Paris, France.
Isabelle Kone-PautERN RITA European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Disease Network, Utrecht, Netherlands.
Linda Rossi-SemeranoERN RITA European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Disease Network, Utrecht, Netherlands.
Isabelle MelkiPediatric Department, Trousseau Hospital, AP-HP, Paris, France.
Brigitte Bader-MeunierERN RITA European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Disease Network, Utrecht, Netherlands.
Bénédicte NevenERN RITA European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Disease Network, Utrecht, Netherlands.
Pierre QuartierERN RITA European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Disease Network, Utrecht, Netherlands.
Guilaine BoursierDepartment of Molecular Genetics and Cytogenomics, Rare and Auto Inflammatory Diseases Unit, CHU Montpellier, University of Montpellier, Montpellier, France.
Laurence CuissetGenetic Department, Cochin Hospital, AP-HP, Paris, France.
Gilles GrateauInternal Medicine Department, Tenon Hospital, AP-HP, Paris, France.
Véronique HentgenPediatric Department, Versailles Hospital, Le Chesnay, France.
Sophie Georgin-LavialleInternal Medicine Department, Tenon Hospital, AP-HP, Paris, France. sophie.georgin-lavialle@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAt present, there are no data on the relationship between colchicine dose and weight in patients with Familial Mediterranean Fever (FMF). We aimed at describing the daily colchicine dose in a cohort of FMF patients.

methodsFrom 2016 to 2023, a retrospective evaluation of prospectively followed homozygous FMF patients at the French National Reference Centre was performed. RESULTS AND

conclusionsOut of 272 patients, 149 were women (57.8%), with a mean age of 43 years old. The mean weight was 67.8 kg and body mass index 24,2 kg/m². Colchicine was taken by 96% of patients. A subgroup of 30 patients received 2.5 mg/day: they were mostly women (n = 23; 76.7%; p = 0.018), with a lower mean weight (p = 0.019); indeed, 26/30 (87%) weighed < 50 kg. Female sex correlated with higher values of daily colchicine dose (p = 0.0208); weight was not associated with colchicine dose (p = 0.4073). No toxicity has been noted in patients treated with 2.5 mg/day, including patients weighing < 50 kg, and most of these patients were women. We may speculate that the clinical picture of female patients requiring an increased dose of colchicine may be related to the hormonal background, with a possible exaggeration of pyrin activation. This is the first study to examine the question of colchicine dosage in relation to weight of FMF adult patients and to highlight a possible link with female gender. We advise clinicians to explain that colchicine treatment may be used daily up to 2.5 mg without toxicity.

Indexed as

ColchicineFamilial Mediterranean FeverAdultBody WeightCohort StudiesDose-Response Relationship, DrugFemaleHumansMaleMiddle AgedRetrospective StudiesSex FactorsYoung AdultColchicineColchicineFamilial Mediterranean FeverFemale sexPosologyWeight

Identifiers

PMID40108720
PMCPMC11921474

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.