SynthesisJournal of applied clinical medical physics2025
A systematic review of electron FLASH dosimetry and beam control mechanisms utilized with modified non-clinical LINACs.
Synthesis in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of electron FLASH dosimetry and beam control mechanisms utilized with modified non-clinical LINACs.Journal of applied clinical medical physics · 2025Pooled it
- Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.Medical physics · 2026Article
- Article
- Ultra-high dose rate electron FLASH beam irradiation using a modified clinical linear accelerator.PloS one · 2026Article
- Factors Influencing the Biological Effects of FLASH Irradiation.Antioxidants (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFLASH has been shown to spare normal tissue toxicity while maintaining tumor control. However, existing irradiation platforms and dosimetry are not compatible. Consequently, an abundance of FLASH delivery devices and new dosimetry across all modalities has been created. Many review articles concluded that dosimetry is modality-dependent. Focusing on electrons, researchers have modified clinical LINACs to enable FLASH dose rates. Modified LINACs caused the development of unique control systems that have yet to be characterized. Improvement could be made when considering the organization of reviews. PURPOSE: To systematically perform a literature survey on electron FLASH dosimetry and beam control mechanisms with modified LINACs, detail where articles originated, and organize the results.
methodsA literature survey was performed from two websites using specified keywords and sifted results to find articles that fit the criteria. The results were organized in tables and summaries effectively by matching up dosimeters with their measurement goal, referring to their specific models, outlining the irradiation conditions they were tested in, and detailing their calibration procedure. Furthermore, included was the unique topic of control mechanisms.
resultsTwenty-eight matches were found. Various dosimeters were examined to measure absorbed dose, beam characteristics (BC), dose per pulse (DPP), and pulse counting (PC). Specific detectors and the irradiation conditions are organized and presented in a table. Each model's pros and cons are presented in another table for further consideration. A third table is provided to detail beam control methods.
conclusionsDosimetry is majorly film-based for absorbed dose and beam characteristic measurements. Many candidates for dosimeters for the use of DPP and PC have been tested, but they have yet to be tested without limitations. Beam control mechanisms primarily consist of unacceptable delivery errors. Many suggestions for improvement were given, mainly consisting of finding new dosimeters and modulating the dose DPP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.