A stability-indicating potentiometric platform for assaying Metoprolol succinate and felodipine in their tablets and human plasma.

Haitham A El Fiky, Mahmoud A Tantawy, Dina A Ahmed, Maha F Abd El Ghanyd, Amr M Badawey, Nermine V Fares

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Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Haitham A El FikyPharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo, Egypt.

Mahmoud A TantawyPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, ET-11562, Egypt. mahmoud.eltantawy@pharma.cu.edu.eg.

Dina A AhmedPharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo, Egypt.

Maha F Abd El GhanydAnalytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Amr M BadaweyPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, ET-11562, Egypt.

Nermine V FaresAnalytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solid contact electrodes are prevalent in analytical applications due to their superior performance compared to traditional electrodes. Nonetheless, these electrodes have been observed to develop a water layer, which compromises their stability. In this study, we introduce an innovative solid contact ion selective electrode designed to mitigate this issue by incorporating multi-walled carbon nanotubes. This system was utilized for potentiometric sensing of metoprolol and felodipine. Furthermore, molecular imprinted polymer was developed to enhance selectivity for determination of felodipine. The electrode modified with multi-walled carbon nanotubes was employed for the quantification of metoprolol, exhibiting a Nernstian slope of 55.23 mV/decade over a linear concentration range of 1.0 × 10

Indexed as

FelodipineLogimax®MetoprololMolecular imprinted polymerMulti-walled carbon nanotubes

Identifiers

PMID40108631

DOI10.1186/s13065-025-01435-z

PMCPMC11924619

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